Summary
We have studied the interaction of erythromycin with theophylline.
We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg·kg−1) over 1 h, followed by a maintenance infusion (0.5 mg·kg−1·h−1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion.
Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations of theophylline was seen during erythromycin treatment. The plasma clearance of theophylline was reduced in 9 of the 10 subjects. Renal clearance increased correspondingly, but the change was not statistically significant.
Serum concentrations of erythromycin fell significantly, by more than 30%, with concurrent theophylline medication.
We conclude that an interaction between theophylline and erythromycin, affecting both drugs, can be shown with concentrations of the drugs within the therapeutic range.
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Paulsen, O., Höglund, P., Nilsson, L.G. et al. The interaction of erythromycin with theophylline. Eur J Clin Pharmacol 32, 493–498 (1987). https://doi.org/10.1007/BF00637676
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DOI: https://doi.org/10.1007/BF00637676