Summary
The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days.
During prednisolone administration antipyrine clearance decreased from 54.9±14.8 to 51.7±14.6 ml/min (mean±SD; p<0.05).
The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.
References
Beckenridge A, Burke CW, Davies DS, Orme MLE (1973) Immediate decrease by hydrocortisone of the plasma half-life of antipyrine. Br J Pharmacol 47: 434–436
Flanagan RJ, Richens A (1974) The influence of elevated plasma hydrocortisone concentrations on antipyrine metabolism in man. Br J Clin Pharmacol 1: 409–412
Leavengood DC, Bunker-Soler AL, Nelson HS (1983) The effect of corticosteroids on theophylline metabolism. Ann Allergy 50: 249–251
Breimer DD, Lilly W, Richter E (1978) Influence of corticosteroids on hexobarbital and tolbutamide disposition. Clin Pharmacol Ther 24: 208–212
Elfstrom J, Lindgren S (1978) The human metabolism of phenazone after hydrocortisone administration. Eur J Clin Pharmacol 13: 69–72
Klintmalm G, Sawe J (1984) High dose methylprednisolone increase plasma cyclosporin levels in renal transplant recipients. Lancet 1: 731
Arrhenius E (1968) Effects on microsomal N- and C-oxygenation of aromatic amines by in vivo corticosteroids or aminofluorene treatment, diet or stress. Cancer Res 28: 264–273
Shukla VK, Garg SK, Mathur VS (1984) Influence of prednisolone on antipyrine and chloramphenicol disposition in the rabbit. Pharmacology 29: 117–120
Døssing M, Poulsen HE, Andreasen PB, Tygstrup N (1982) A simple method for determination of antipyrine clearance. Clin Pharmacol Ther 32: 392–396
Laybourn C, Tønnesen P, Loft S, Sonne J, Døssing M (1986) Pulmonary disease and antipyrine clearance. Clin Pharmacol Ther 40: 415–419
Pilsgaard H, Poulsen HE (1984) A one sample method for antipyrine clearance determination in rats. Pharmacology 29: 110–116
Vesell ES (1979) The antipyrine clearance in clinical pharmacology: Conceptions and misconceptions. Clin Pharmacol Ther 26: 275–286
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Loft, S., Simonsen, K., Evald, T. et al. Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease. Eur J Clin Pharmacol 33, 89–91 (1987). https://doi.org/10.1007/BF00610387
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DOI: https://doi.org/10.1007/BF00610387