Summary
In a randomised double-blind cross-over study, 8 normal subjects received propranolol 80 mg twice daily with omeprazole 20 mg or identical placebo each morning. Propranolol kinetics were measured on day 8 of both treatment periods.
Areas under the propranolol concentration/time curves were not significantly increased by omeprazole treatment: off treatment mean 787.6, on treatment 802.5 ng−1·ml·h. Maximum and minimum steady-state propranolol concentrations were similarily unaffected. Omeprazole also failed to increase the clinical effect of propranolol, as assessed by exercise tests on Day 8 of treatment.
We conclude that omeprazole in the dose likely to be used for peptic ulcer has no significant effect on the kinetics or action of propranolol.
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References
Henry DA, Somerville KW, Kitchingman G, Langman MJS (1984) Omeprazole: Effects on oxidative drug metabolism. Br J Clin Pharmacol 18: 195–200
Gugler R, Jensen JC (1985) Omeprazole inhibits oxidative drug metabolism. Gastroenterology 89: 1235–1241
Jensen JC, Gugler R (1986) Inhibition of liver cytochrome P-450 by omeprazole. Br J Clin Pharmacol 21: 328–330
Bruce RA (1971) Exercise testing of patients with coronary heart disease. Ann Clin Res 3: 323–332
Smith MT, Livingstone I, Hooper WD, Eadie MJ, Triggs EJ (1983) Propranolol, propranolol glucuronide and naphoxylactic acid in breast milk and plasma. Ther Drug Monit 5: 87–93
Mihaly GW, Prichard PJ, Smallwood RA, Yeomans ND, Louis WJ (1983) Simaltaneous high performance liquid chromatographic analysis of omeprazole and its sulphone and sulphide metabolites in human plasma and urine. J Chromatogr 278: 311–319
Reimann IW, Klotz U, Siems B, Frolich JC (1981) Cimetidine increases steady state plasma levels of propranolol. Br J Clin Pharmacol 12: 785–790
Feely J, Wilkinson GR, Wood AJJ (1981) Reduction of liver blood flow and propranolol metabolism by cimetidine. N Eng J Med 304: 692–695
Cooperative Study (1984) Omeprazole in duodenal ulceration: Acid inhibition, symptom relief, endoscopic healing, and recurrence. Br Med J 289: 525–528
Howden CW, Kenyon CJ, Beastall GH, Reid JL (1986) Inhibition by omeprazole of adrenocortical response to ACTH: Clinical studies and experiments on bovine adrenal cortex in vitro. Clin Sci 70: 99–102
Lloyd-Davies KA, Rutgersson K, Solvell L (1986) Omeprazole in Zollinger-Ellison Syndrome: Four year international study. Gastroenterology 90: 1523
Henry DA, Gerkens JF, Brent PJ, Dosen PJ (1986) Omeprazole: Effects on oxidative drug metabolism in the rat. Clin Exp Pharmacol Physiol 13: 377–381
Webster LK, Jones DB, Mihaly GW, Smallwood RA (1984) Effects of omeprazole and polyethylene glycol-400 on antipyrine elimination by the isolated perfused rat liver. J Pharm Pharmacol 36: 470–472
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Henry, D., Brent, P., Whyte, I. et al. Propranolol steady-state pharmacokinetics are unaltered by omeprazole. Eur J Clin Pharmacol 33, 369–373 (1987). https://doi.org/10.1007/BF00637632
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DOI: https://doi.org/10.1007/BF00637632