Summary
The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose.
Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7–57.9 h in these elderly men.
The elimination half-life was twice as long when compared to a study previously performed in young volunteers.
References
Baumel IP, Gallagher BB, Mattson RH (1972) Phenylethyl-malonamide (PEMA). An important metabolite of primidone. Arch Neurol 27: 34–41
Bjornsson TD (1979) Use of serum creatinine concentrations to determine renal function. Clin Pharmacokinet 4: 200–222
Calzetti S, Findley LJ, Pisani F, Richens A (1981) Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry 44: 932–934
Cottrell PR, Streete JM, Berry DJ, Schafer J, Pisani F, Perucca E, Richens A (1982) Pharmacokinetics of phenylethylmalonamide (PEMA) in normal subjects and in patients treated with Antiepileptic drugs. Epilepsia. 23: 307–313
Davies DF, Shock NW (1950) Age changes in glomerular filtration rate effective renal plasma flow and tubular excretory capacity in adult males. J Clin Invest 29: 496–507
Gallagher BB, Baumel IP, Mattson RH (1972) Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration. Neurology 22: 1186–1192
Heipertz R, Guthoff A, Bernhardt W (1979) Primidone metabolism in renal insufficiency and acute intoxication. J Neurol 221: 101–104
O'Brien MD, Upton AR, Toseland PR (1981) Benign familial tremor treated with primidone. Br Med J 282: 178–180
Pisani F, Richens A (1983) Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration. Clin Pharmacokinet 8: 272–276
Stern EL (1977) Possible phenylethylmalonamide (PEMA) intoxication. Ann Neurol 2: 356–357
Streete JM, Berry DJ (1987) Gas chromatographic analysis of phenylethylmalonamide in human plasma. J Chromatogr 416: 281–291
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Streete, J.M., Berry, D.J., Newberry, J.E. et al. Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men. Eur J Clin Pharmacol 33, 431–434 (1987). https://doi.org/10.1007/BF00637644
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DOI: https://doi.org/10.1007/BF00637644