Summary
The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (>1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy.
The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls.
Thus, the combination of triameterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.
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Widmann, L., Dyckner, T. & Wester, PO. Effects of triameterene on serum and skeletal muscle electrolytes in diuretic-treated patients. Eur J Clin Pharmacol 33, 577–579 (1988). https://doi.org/10.1007/BF00542490
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DOI: https://doi.org/10.1007/BF00542490