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Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors

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Summary

In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion.

Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. The PAC response to sodium depletion was reduced to 155 (29) pg/ml by co-dergocrine.

No significant PAC changes were found in patients maintained on a normal sodium intake. In addition the drug did not significantly modify plasma renin activity (PRA) in either experimental group.

These results suggest that the dopaminergic inhibition of aldosterone secretion in man is mediated by DA2-receptors in the adrenal cortex.

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Authors and Affiliations

  1. Department of Internal Medicine, St. Orsola Hospital, Brescia, Italy

    C. Lombardi, R. De Cotiis & C. Spedini

  2. Institute of Chemistry, School of Medicine, University of Brescia, Brescia, Italy

    G. Pizzoccolo & A. Albertini

  3. Institute of Pharmacology and Experimental Therapeutics, School of Medicine, University of Brescia, Brescia, Italy

    C. Missale, M. Memo & P. F. Spano

Authors
  1. C. Lombardi
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  2. C. Missale
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  3. R. De Cotiis
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  4. C. Spedini
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  5. G. Pizzoccolo
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  6. M. Memo
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  7. A. Albertini
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  8. P. F. Spano
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Lombardi, C., Missale, C., De Cotiis, R. et al. Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors. Eur J Clin Pharmacol 35, 323–326 (1988). https://doi.org/10.1007/BF00558273

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  • DOI: https://doi.org/10.1007/BF00558273

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