Skip to main content
Log in

Transcutaneous absorption of naproxen gel

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The kinetics of naproxen was studied in healthy volunteers after cutaneous application of gels containing 5 and 10% of the drug. Bioavailability was estimated from serum concentration and cumulative urinary metabolite excretion data, both determined up to 96 hours after drug administration.

The mean bioavailability after the 10% gel was 1.1% (serum data) and 1.0% (urine data), and after the 5% gel it was 2.1% (serum data) and 1.8% (urine data).

Despite the small amount of naproxen absorbed, a potential pharmacological effect, due to cutaneous accumulation of the drug following topical administration, may be suggested from the course of the serum concentration-time curves.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Brune K (1987) Percutaneous antirheumatic therapy: A reappraisal. In: Andrianakos A, Kappou I, Marikakis M, Moutsopoulos H (eds). Eurorheumatology. Proceedings of the XIth European Congress of Rheumatology. H. Tagas and Son Press, Athens, pp 348–349

    Google Scholar 

  2. Van Loenhout J, Van Ginneken CAM, Ketelaars H, Kimenai P, Tan Y, Gribnau FWJ (1982) A high-performance liquid chromatographic method for the quantitative determination of naproxen and desmethylnaproxen in biological samples. J Liquid Chromatogr 5: 549–561

    Google Scholar 

  3. Van Den Ouweland FA, Gribnau FWJ, Van Ginneken CAM, Tan Y, Van De Putte LBA (1988) Naproxen kinetics and disease activity in rheumatoid arthritis: a within-patient study. Clin Pharmacol Ther 43: 79–85

    Article  PubMed  Google Scholar 

  4. Riess W, Schmid K, Botta L, Kobayashi K, Moppert J, Scheider W, Sioufi A, Strusberg A, Tomasi M (1986) Percutaneous absorption of diclofenac. Arneimittelforsch/Drug Res 36: 1092–1096

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

van den Ouweland, F.A., Eenhoorn, P.C., Tan, Y. et al. Transcutaneous absorption of naproxen gel. Eur J Clin Pharmacol 36, 209–211 (1989). https://doi.org/10.1007/BF00609198

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00609198

Key words

Navigation