Summary
The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
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Hirata, Y., Fukui, K., Dan, Y. et al. Renal and hormonal effects of alpha1-adrenoceptor blockade by bunazosin in essential hypertension. Eur J Clin Pharmacol 36, 575–578 (1989). https://doi.org/10.1007/BF00637738
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DOI: https://doi.org/10.1007/BF00637738