Skip to main content
SpringerLink
Log in

Comparative pharmacokinetics of zidovudine (AZT) and its metabolite (G.AZT) in healthy subjects and HIV seropositive patients

  • Letters To The Editor
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Good SS, Reynolds DJ, De Miranda P (1988) Simultaneous quantification of zidovudine and its glucuronide in serum by high performance liquid chromatography. J Chromatogr 431: 123–133

    Google Scholar 

  2. McCloskey SE, Rege AB, Lertora JJL, George WJ, Agrawal KC, Hyslop NE (1988) Monitoring AZT plasma levels in patients with HIV-infection. Clin Pharmacol Ther 43 (2): 123

    Google Scholar 

  3. Chinnock BJ, Fletcher C, Rhame F, Chace B, Sullivan C, Balfour HH (1987) Pharmacokinetics of azidothymidine in 5 AIDS patients. 3rd International Conference on AIDS — Washington, June 1987 (Abstract no.231)

  4. Blum MR, Liao SHT, Good SS, Drucker J, Kirk LE, De Miranda P (1986) Pharmacokinetics of azidothymidine following intravenous and oral administration. 2nd International Conference on AIDS — Paris, June 1986 (Abstract no.488)

  5. Klecker RW, Collins JM, Yarchoan R, Thomas R, Jenkins JF, Broder S, Myers CE (1987) Plasma and cerebrospinal fluid pharmacokinetics of 3′ azido −3′ deoxythymidine, a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin Pharmacol Ther 41: 407–412

    Google Scholar 

  6. De Miranda P, Weller S, Maha M, Lifson AR (1988) Pharmacokinetics of zidovudine and acyclovir during concurrent drug administration in asymptomatic men with HIV infection. 4th International Conference on AIDS — Stockholm, June 1988 (Abstract no.3136)

  7. Blum MR, Liao SHT, Good SS, De Miranda P (1987) Pharmacokinetics and metabolism of zidovudine in man. Wellcome International Antiviral Symposium — Monte-Carlo, December 1987

  8. De Miranda P, Brunette TC, Good SS (1987) Disposition and pharmacokinetics of the antiviral drug 3′ azido −3′ deoxythymidine (Retrovir) in monkeys and rats. 27th ICAAC — New-York, October 1987 (Abstract no.378)

Download references

Author information

Authors and Affiliations

  1. Pharmacie Clinique, Hôpital Bicêtre, France

    E. Singlas, J. C. Pioger & A. M. Taburet

  2. Laboratoire Wellcome, Pairs, France

    S. Colaneri

  3. Departement de Néphrologie, Hôpital de Boisguillaume, Rouen, France

    J. P. Fillastre

Authors
  1. E. Singlas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Pioger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. M. Taburet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Colaneri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. P. Fillastre
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singlas, E., Pioger, J.C., Taburet, A.M. et al. Comparative pharmacokinetics of zidovudine (AZT) and its metabolite (G.AZT) in healthy subjects and HIV seropositive patients. Eur J Clin Pharmacol 36, 639–640 (1989). https://doi.org/10.1007/BF00637752

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00637752

Key words

Search

Navigation