Skip to main content
SpringerLink
Log in

The direct effects of metformin on platelet function in vitro

  • Letter To The Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sirtori C, Catapano A, Ghiselli GC, Shore B, Shore V (1978) Effects of metformin on lipoprotein composition in rabbits and man. Prot Biol Fluids 25: 379–383

    Google Scholar 

  2. Gustafson A, Bjorntorp P, Martin F (1971) Metformin administration in hyperlipidaemic states. Acta Med Scand 190: 491–494

    Google Scholar 

  3. Janka HU (1985) Platelet and endothelial function tests during metformin treatment in diabetes mellitus. Horm Metab Res 12: 120–122

    Google Scholar 

  4. Marchetti P, Benzi L, Gregorio F, Giannecchini M, Cecchetti P, Di Cianni G, Giannarelli R, Zappella A, Ciccarone AM, Masoni A, Giovannitti MG, Brunetti P, Navalesi R (1978) Plasma metformin concentrations and their relation to metabolic effects in type II diabetic patients. J Endocrinol Invest 10: 154

    Google Scholar 

  5. De Caterina R, Giannessi D, Gazzetti P, Bernini W (1984) Thromboxane B2 generation during ex-vivo platelet aggregation. J Nucl Med Allied Sci 28: 185–1916

    Google Scholar 

  6. Marquie G (1978) Effect of metformin on lipid metabolism in the rabbit aortic wall. Atherosclerosis 30: 165–175

    Google Scholar 

  7. Sirtori C, Tremoli E, Sirtori M, Conti F, Paoletti R (1977) Treatment of hypertriglyceridemia with metformin. Atherosclerosis 26: 583–587

    Google Scholar 

  8. Descovich G, Montaguti U, Ceredi C, Cocuzza E, Sirtori C (1978) Long-term treatment with metformin in a large cohort of hyperlipidaemic patients. Artery 4: 348–359

    Google Scholar 

  9. Sirtori C, Franceschini G, Gianfranceschi G, Sirtori M, Montanari G, Bosisio E, Mantero E, Bondiali A (1984) Metformin improves peripheral vascular flow in non-hyperlipidemic patients with arterial disease. J Cardiovasc Pharmacol 6: 914–924

    Google Scholar 

  10. Fitzgerald GA, Pedersen AK, Patrono C (1983) Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation 67: 1174–1177

    Google Scholar 

  11. Grant JA, Scrutton MC (1980) Positive interaction between agonists in the aggregation response to human blood platelets. Interaction between ADP and adrenaline and vasopressin. Br J Haematol 44: 109–125

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. C.N.R. Institute of Clinical Physiology, Pisa, Italy

    R. De Caterina, P. Marchetti, W. Bernini, R. Giannarelli, D. Giannessi & R. Navalesi

Authors
  1. R. De Caterina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Marchetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Bernini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Giannarelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Giannessi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Navalesi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

De Caterina, R., Marchetti, P., Bernini, W. et al. The direct effects of metformin on platelet function in vitro. Eur J Clin Pharmacol 37, 211–213 (1989). https://doi.org/10.1007/BF00558236

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00558236

Key words

Search

Navigation