Summary
Salbutamol was administered intravenously to 5 patients with renal function impairment for estimation its pharmacokinetic parameters. The mean terminal half-life was 256 min, similar to previously reported values in healthy adults. The mean clearance (167 ml/min) and the mean volume of distribution (55 l) were decreased. These parameters were not correlated with the creatinine clearance. A slight but significant decrease was observed in the plasma potassium level up to 125 min after the salbutamol infusion. The heart rate was significantly increased, and the increase in 3 patients was correlated with the salbutamol concentration. The biological effects of the drug were less marked than expected.
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Rey, E., Luquel, L., Richard, M.O. et al. Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects. Eur J Clin Pharmacol 37, 387–389 (1989). https://doi.org/10.1007/BF00558505
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DOI: https://doi.org/10.1007/BF00558505