Summary
The pharmacokinetics of cefoperazone was studied in eleven cirrhotic patients with ascites after i.v. administration of a single dose of 15 mg·kg−1 (n=7) or after three doses of 15 mg·kg−1 given at 12 h intervals (n=4). The concentrations of cefoperazone in serum and ascitic fluid were determined by HPLC. The peak serum cefoperazone concentration after a single i.v. injection of 15 mg·kg−1 was 96.0 mg·l−1. The serum elimination half-life was longer (5.0 h) than in normal subjects. The penetration of cefoperazone into ascites was satisfactory (32.3% and 58.3% after single and repeated injections, respectively).
Ascitic fluid concentrations of cefoperazone exceeded 5.4 mg·ml−1 from 0.5 to 6 h after the single i.v. injection, levels which are well above the MIC of most pathogens found in spontaneous bacterial peritonitis. Adjustment of the dose of cefoperazone in cases of severe hepatic insufficiency does not appear to be necessary provided that renal function is normal.
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References
Conn HO, Fessel SM (1971) Spontaneous bacterial peritonitis in cirrhosis: Variations on a theme. Medicine 50: 161–197
Pinzello G, Simonetti RG, Craxi A, Di Piazza S, Spano C, Pagliaro L (1983) Spontaneous bacterial peritonitis: A prospective investigation in predominantly non-alcoholic cirrhotic patients. Hepatology 3: 545–549
Hoffs J, Canawati H, Sapico F, Hopkins R, Weiner J, Montogomerie J (1982) Spontaneous bacterial peritonitis. Hepatology 2: 399–407
Crossley IR, Williams R (1985) Spontaneous bacterial peritonitis. Gut 26: 325–331
Wilcox CM, Dismukes WE (1987) Spontaneous bacterial peritonitis. Review of pathogenesis, diagnosis and treatment. Medicine 66: 447–456
Pugh RN, Murray-Lyon IM, Dawson JL (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60: 646–649
Galizzi J, Long RG, Billing BH, Sherlock S (1978) Assessment of the14C aminopyrine breath test in liver disease. Gut 19: 40–45
Brisson AM, Fourtillan JB (1981) Determination of cephalosporins in biological material by reversed-phase liquid column chromatography. J Chromatogr 223: 393–399
Gibaldi M, Perrier D (1975) Pharmacokinetics, drugs and the pharmaceutical, vol. 1. Marcel Dekker, New York
Greenfield RA, Gerber AU, Craig WA (1983) Pharmacokinetics of cefoperazone in patients with normal and impaired hepatic and renal function. Rev Infect Dis 5: S127-S135
Boscia JA, Korzeniowski OM, Snepar R, Kobosa WD, Levison ME, Kaye D (1983) Cefoperazone pharmacokinetics in normal subjects and patients with cirrhosis. Antimicrob Agents Chemother 23: 385–389
Cochet B, Belaieff J, Allaz AF, Rudhardt M, Balant L, Fabre J (1981) Serum levels and urinary excretion of cefoperazone in patients with hepatic insufficiency. Infection 9 [Suppl 1]: 37–38
Boscia JS, Korzeniowski OM, Kobasa WD, Rocha H, Levison ME, Kaye D (1983) Pharmacokinetics of cefoperazone in normal subjects and patients with hepatosplenic schistosomiasis. J Antimicrob Chemother 12: 407–410
Bolton WK, Sheld WM, Spyker DA, Sande MA (1981) Pharmacokinetics of cefoperazone in normal volunteers and subjects with renal insufficiency. Antimicrob Agents Chemother 19: 821–825
Benoni G, Arosio E, Raimond MG, Pancera P, Lechi A, Velo GP (1985) Pharmacokinetics of ceftazidine and ceftriaxone and their penetration into the ascitic fluid. J Antimicrob Chemother 16: 267–273
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Van Gossum, A., Quenon, M., Van Gossum, M. et al. Penetration of cefoperazone into ascites. Eur J Clin Pharmacol 37, 577–580 (1989). https://doi.org/10.1007/BF00562548
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DOI: https://doi.org/10.1007/BF00562548