Summary
The effect of haemodialysis on the pharmacokinetics of oral famotidine has been studied in five elderly anuric patients. Famotidine 20 mg was administered in a cross-over design to patients on and not on haemodialysis.
The elimination rate constant of haemodialysis (k) was 4.6-fold larger than the systemic elimination rate constant (ke). Although the mean maximum serum concentration of famotidine during haemodialysis (141.5 ng·ml−1) was not significantly lower than that without haemodialysis (195.6 ng·ml−1), the AUC up to 5 h during haemodialysis was significantly decreased to 58.1% of the value without it.
The data suggest that famotidine is dialysable by haemodialysis.
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References
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Inotsume, N., Nishimura, M., Nakano, M. et al. Removal of famotidine by haemodialysis in elderly anuric patients. Eur J Clin Pharmacol 38, 313–314 (1990). https://doi.org/10.1007/BF00315039
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DOI: https://doi.org/10.1007/BF00315039