Summary
The attempt has been made to define the optimal dose regimen of clonazepam in newborns suffering from neonatal convulsions.
Results obtained from 22 patients (GA 28–41 weeks; PNA 4 h to 23 days) indicated that a dose of 0.1 mg/kg every 24 h was satisfactory in the majority of the patients. It is recommended as a starting regimen.
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References
Aicardi J (1979) Recent advances in drug therapy of some forms of childhood epilepsy. Paediatrician [Suppl 1]: 119–130
Andre M, Boutroy MJ, Dubruc C, Thenot JP, Bianchetti G, Sola L, Vert P, Morselli PL (1986) Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures. Eur J Clin Pharmacol 30: 585–590
Baruzzi A, Bordo B, Bossi L, Castelli D, Gerna M, Tognoni G, Zagnoni P (1977) Plasma levels of di-n-propylacetate and clonazepam in epileptic patients. Int J Clin Pharmacol Biopharm 15: 403–408
Browne TR (1978a) Drug therapy reviews: drug therapy of status epilepticus. Am J Hosp Pharm 35: 915–922
Browne TR (1978b) Clonazepam. N Engl J Med 299: 812–816
Congdon PJ, Forsythe WI (1980) Intravenous clonazepam in the treatment of status epilepticus in children. Epilepsia 21: 97–102
De Silva JAF, Puglisi CV, Munno N (1974) Determination of clonazepam and flunitrazepam in blood and urine by electron capture CLC. J Pharm Sci 63: 520–527
Dreifuss FE, Penry JK, Rose SW, Kupferberg HJ, Dyden P, Sato S (1975) Serum clonazepam concentrations in children with absence seizures. Neurology 25: 255–258
Knop HJ, Van der Kleijn E, Edmunds LC (1974) Pharmacokinetics of clonazepam in man and laboratory animals. In: Schneider et al. (eds) Clinical Pharmacology of antiepileptic drugs. Springer, Berlin Heidelberg New York, pp 247–260
Iwakawa Y, Niwa T, Suzuki H (1986) Clonazepam-induced tonic seizure. No To Hattatsu 18: 347–353
Morselli PL (1978) Clinical significance of monitoring plasma levels of benzodiazepine tranquilizers and antiepileptic drugs. In: Deniker P, Radouco-Thomas C (eds) Neuropsychopharmacology. Villeneuve Pergamon, Oxford, pp 877–888
Pinder RM, Brodgen RN, Speight TM, Avery GS (1976) Clonazepam: a review of its pharmacological properties and therapeutic efficacy in epilepsy. Drugs 12: 321–361
Sato S (1989) Clonazepam. In: Levy R, Mattson R, Meldrum B, Penry JK, Dreifuss FE (eds) Antiepileptic drugs, sed. Raven Press, New York, pp 765–784
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Andre, M., Boutroy, M.J., Bianchetti, G. et al. Clonazepam in neonatal seizures: dose regimens and therapeutic efficacy. Eur J Clin Pharmacol 40, 193–195 (1991). https://doi.org/10.1007/BF00280077
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DOI: https://doi.org/10.1007/BF00280077