Summary
In experimental animal models nonsteroidal anti-inflammatory drugs may influence gastrointestinal motility, but as evidence is lacking in man. The effect of diclofenac sodum 75 mg i.m. on the motor response of the upper gastrointestinal tract to food has been studied by manometry in 9 healthy volunteers. Diclofenac had no effect on the motor activity of the stomach, duodenum, or jejunum after a 605 kcal meal.
References
Frankhuizen AL, Bonta IL (1975) Role of prostaglandins in tone and effector reactivity of the isolated rat stomach preparation. Eur J Pharmacol 31: 44–52
Pantoja GL, Defilippi C, Valenzuela JE, Csendes A (1979) Nonsteroidal antiinflammatory drugs: effect on pyloric sphincter and duodenogastric reflux. Dig Dis Sci 24: 217–220
Fioramonti J, Bueno L (1980) Gastrointestinal myoelectric activity disturbance in gastric ulcer disease in rats and dogs. Dig Dis Sci 25: 575–580
Sanders KM, Szurzewski JH (1981) Does endogenous prostaglandin affect gastric antral motility? Am J Physiol 241: G191-G195
Dooley COP, Mello D, Valenzuela JE (1985) Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man. Dig Dis Sci 30: 513–521
Mersereau WA, Hinchey EJ (1981) Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone-treated rat. Surgery 90: 516–522
Mersereau WA, Hinchey EJ (1982) Prevention of phenylbutazone ulcer in the rat by glucose: role of glycoprivic receptor system. Am J Physiol 242: G429-G432
Takeuchi K, Ueki S, Okabe S (1988) Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 31: 1114–1122
Mersereau WA, Hinchey EJ (1988) Relationship between the gastric myoelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin treated rats. Dig Dis Sci 33: 200–208
Ueki S, Takeuchi K, Okabe S (1988) Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Dig Dis Sci 33: 209–216
Thompson DG, Wingate DL, Archer L, Benson MJ, Green WJ, Hardy RJ (1980) Normal patterns of human upper small bowel motor activity recorded by prolonged radiotelemetry. Gut 21: 500–506
Kerlin P, Phillips S (1982) Variability of motility of the ileum and jejunum in healthy humans. Gastroenterology 82: 694–700
Malagelada JR, Camilleri M, Stanghellini V (1986) Manometric diagnosis of gastrointestinal motility disorders. Thieme, New York
Narducci F, Bassotti G, Granata MT, Gaburri M, Farroni F, Palumbo R, Morelli A (1986) Functional dyspepsia and chronic idiopathic gastric stasis. Role of endogenous opiates. Arch Intern Med 146: 716–720
Bassotti G, Gaburri M, Farroni F, Fiorucci S, Pelli MA, Morelli A (1987) Selective gastric stasis for solid food. Ital J Gastroenterol 19: 91–94
Malagelada JR, Stanghellini V (1985) Manometric evaluation of functional upper gut symptoms. Gastroenterol 88: 1223–1231
SAS Institute Inc (1987) SAS/STAT (TM) Guide for personal computer. SAS Institute Inc; Carey, NC
Möller H, Stüber W, Czechanowski B, Gundert-Remy U (1984) Bioverfügbarkeit von Diclofenac-Fertigarzneimitteln für die orale, rektale und intramuskuläre Applikation. Pharm Ztg 129: 2841–2844
Todd PA, Sorkin EM (1988) Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 35: 244–285
Sanders K (1984) Role of prostaglandins in regulating gastric motility. Am J Physiol 247: G117-G126
Thor P, Konturek JW, Konturek SJ, Anderson JH (1985) Role of prostaglandins in control of intestinal motility. Am J Physiol 248: G353-G359
Bueno L, Fargeas MJ, Fioramonti J, Primi MP (1985) Central control of intestinal motility by prostaglandins: a mediator of the actions of several peptides in rats and dogs. Gastroenterol 88: 1888–1894
Whittle BJ, Vane JR (1987) Prostanoids as regulators of gastrointestinal function. In: Johnson LR. Physiology of the gastrointestinal tract. 2nd ed. Raven Press, New York, pp 143–180
Burks TF (1987) Actions of drugs on gastrointestinal motility. In: Johnson LR. Physiology of the gastrointestinal tract. 2nd ed. Raven Press, New York, pp 723–743
Ku EC, Lee W, Kothari HV, Scholer DW (1986) Effect of diclofenac sodium on the arachidonic acid cascade. Am J Med 80 [Suppl 4B]: 18–23
Brogden RN, Heel RC, Pakes GE, Speight TM, Avery GS (1980) Diclofenac sodium: a review of its pharmacological porperties and therapeutic use in rheumatic diseases and pain of varying origin. Drugs 20: 24–48
Lundstam SOA, Leissner K-H, Wahlander LA, Kral JG (1982) Prostaglandin-synthetase inhibition with diclofenac sodium in treatment of renal colic: comparison with use of a narcotic analgesic. Lancet I: 1096–1097
Broggini M, Corbetta E, Grossi E, Borghi C (1984) Diclofenac sodium in biliary colic: a double blind trial. Br Med J 288: 1042
Stanghellini V, Malagelada JR, Zinsmeister A, Go VLM, Kao PC (1983) Stress-induced gastrointestinal motor disturbances in man: possible humoral mechanisms. Gastroenterology 85: 83–91
Estudo cooperative multicentrico (1987) Efeito analgesico do diclofenac sódico em comparaçao ao de dipirona em dores pós-traumáticas. F Méd Br 79: 371–376
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Bassotti, G., Bucaneve, G., Betti, C. et al. Effects of parenteral diclofenac sodium on upper gastrointestinal motility after food in man. Eur J Clin Pharmacol 41, 497–500 (1991). https://doi.org/10.1007/BF00626379
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DOI: https://doi.org/10.1007/BF00626379