Summary
The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design.
Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
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References
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Kamali, F., Adriaens, L., Huang, M.L. et al. Dose proportionality study of loperamide following oral administration of loperamide oxide. Eur J Clin Pharmacol 42, 693–694 (1992). https://doi.org/10.1007/BF00265940
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DOI: https://doi.org/10.1007/BF00265940