Summary
The 24 h urinary excretion of paracetamol and its conjugates after oral administration of about 15 mg/kg was studied in 24 Chinese and 24 Indian healthy young adult male volunteers living in Singapore.
The Indians excreted a significantly lower fraction of sulphate conjugate (28.9% compared to 35.9% in the Chinese), and a correspondingly higher fraction as glucuronide conjugate (62.2% compared to 54.5% in the Chinese). There was no difference between the ethnic groups in terms of the urinary recovery of unchanged paracetamol (Indians 3.4%, Chinese 3.6%), glutathione-derived cysteine (Indians 2.3% and Chinese 2.2%) and mercapturic acid (Indians 3.6%, Chinese 3.8%) conjugates. The total fraction of administered paracetamol recovered in the urine was 84.7% and 85.7% in the Indian and the Chinese groups, respectively. Although the total glutathione derived conjugates recovered in the two ethnic groups were similar (Indians 5.9%, Chinese 6%), the values were lower than those reported previously for Caucasians in Scotland (9.3%).
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References
Adriaenssens PI, Prescott LF (1978) High performance liquid chromatographic estimation of paracetamol metabolites in Plasma. Br J Clin Pharmacol 6: 87–88
Caldwell J, Davies S, Boote DJ, O'Gorman J (1982) Interindividual variation in the sulphation and glucuronidation of paracetamol and salicylamide in human volunteers. In: Mulder GJ, Caldwell J, Van Kempen GMJ, Vonk RJ (eds), Sulphate Metabolism and sulphate Conjugation. Taylor and Francis, London, pp 251–261
Clements JA, Critchley JAJH, Prescott LF (1984) The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. Br J Clin Pharmacol 18: 481–485
Critchley JAJH, Nimmo GR, Gregson CA, Woolhouse NM, Prescolt LF (1986) Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol 22: 649–657
Howie D, Adriaenssens PI, Prescott LF (1977) Paracetamol metabolism following overdose: application of high performance liquid chromatography. J Pharm Pharmacol 29: 235–237
Kalow W (1982) Ethnic differences in drug metabolism. Clin Pharmacokinet 7: 373–400
Lee HS, Ti TY, Hsu A (1989) Paracetamol metabolism in Chinese and Indians in Singapore. Eur J Clin Pharmacol 36 [suppl]: A200
Mitchell JR, Jollow DJ (1975) Metabolic activation of drugs to toxic substances. Gastroenterology 68: 392–410
Mucklow JC, Fraser HS, Bulpitt CJ, Kahn Clare, Mould G, Dollery CT (1980) Environmental factors affecting paracetamol metabolism in London Factory and office workers. Br J Clin Pharmacol 10: 67–74
Mulder GJ, Jakoby WB (1990) Sulphation. In: Mulder GJ (ed) Conjugation reactions in drug metabolism: An integrated approach. Taylor and Francis, London, pp 107–161
Nash RM, Stein L, Penno MB, Passananti GM, Vesell ES (1984) Sources of interindividual variations in acetaminophen and antipyrine metabolism. Clin Pharmacol Ther 36: 417–430
Prescott LF, Critchley JAJH (1983) The treatment of acetaminophen poisoning. Ann Rev Pharmacol Toxico 23: 87–101
Sommers DK, van Staden DA, Moncrieff J, Schoeman HS (1985) Paracetamol metabolism in African villagers. Hum Toxicol 4: 385–389
Weinshilboum RM (1986) Phenol sulfotransferase in humans: properties, regulation, and function. Fed Proc 45: 2223–2228
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Lee, H.S., Ti, T.Y., Koh, Y.K. et al. Paracetamol elimination in Chinese and Indians in Singapore. Eur J Clin Pharmacol 43, 81–84 (1992). https://doi.org/10.1007/BF02280759
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DOI: https://doi.org/10.1007/BF02280759