Skip to main content
SpringerLink
Log in

Therapeutic lidocaine concentrations have no effect on blood platelet function and plasma catecholamine levels

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The effects of therapeutic plasma concentrations of lidocaine on blood platelet function and plasma catecholamine levels were assessed in 9 healthy subjects.

There were no significant effects on plasma levels ofβ-thromboglobulin, collagen and adenosine diphosphate-stimulated platelet aggregation, thromboxane-B2-concentration in plasma after collagen and ADP stimulated platelet aggregation, or on plasma nor-adrenaline and adrenaline. No significant correlation could be demonstrated between any of the variables tested. Thus, it appeared that lidocaine had no effect on platelets that could be of benefit in acute myocardial infarction.

It should be possible to use lidocaine, in combination with thrombolytic therapies without increasing the risk of bleeding complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Petch MC (1989) Myocardial infarction. In: Julian DG, Camm AJ, Fox KM, Hall RJC, Poole Wilson PA (eds) Diseases of the heart. Baillière Tindall, London, p 1180

    Google Scholar 

  2. Baumgartner HR, Muggli R, Tschopp TB, Turritto VT (1976) Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function. Thromb Haemostasis 35: 124–138

    Google Scholar 

  3. Lewis JC, Kottke BA (1977) Endothelial damage and thrombocyte adhesion in pigeon atherosclerosis. Science 196: 1007–1009

    Google Scholar 

  4. Davies MJ, Thomas AC (1985) Plaque fissuring — the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 53: 363–373

    Google Scholar 

  5. Weiss HJ (1975) Platelet physiology and abnormalities of platelet function. N Engl J Med 293: 531–539

    Google Scholar 

  6. Ellis EF, Oelz O, Roberts LJ II, Ann Payne N, Sweetman BJ, Nies AS, Oates JA (1976) Coronary arterial smooth muscle concentration by a substance released from platelets: Evidence that it is thromboxane A2. Science 193: 1135–1137

    Google Scholar 

  7. Fuster V, Chesebro JH (1981) Current concepts of thrombogenesis: role of platelets. Mayo Clin Proc 56: 102–112

    Google Scholar 

  8. Coker SJ, Ledingham IMcA, Parratt JR, Zeitlin IJ (1981) Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular activity following acute coronary artery occlusion in dogs. Br J Pharmacol 72: 593–595

    Google Scholar 

  9. Coker SJ (1984) Further evidence that thromboxane exacerbates arrhythmias: effects of UK 38485 during coronary occlusion and reperfusion in anaesthetized greyhounds. J Mol Cell Cardiol 16: 633–641

    Google Scholar 

  10. Goldstein DS (1981) Plasma norepinephrine as an indicator of sympathetic neural activity in clinical cardiology. Am J Cardiol 48: 1147–1154

    Google Scholar 

  11. Mills DCB, Roberts GCK (1967) Effects of adrenaline on human blood platelets. J Physiol 193: 443–453

    Google Scholar 

  12. Purchase M, Dustin GJ, Li DMF, Reid MA (1986) Physiological concentrations of ephinephrine potentiate thromboxane A2 release from platelets in the isolated rat heart. Circ Res 58: 172–176

    Google Scholar 

  13. Goldstein DB (1984) The effects of drugs on membrane fluidity. Ann Rev Pharmacol Toxicol 24: 43–64

    Google Scholar 

  14. Cooke ED, Lloyd MJ, Bowcock SA, Pitcher MF (1977) Intravenous lignocaine in prevention of deep venous thrombosis after elective hip surgery. Lancet 11: 797–799

    Google Scholar 

  15. Kirichenko LL, Masenko VP, Nikitin AE, Narynskii AK, Morazova LM (1986) Effects of anti-arrhythmia preparations on thrombocytic and vascular hemostasis. Ter Ark 58: 70–72

    Google Scholar 

  16. Modig J (1985) The role of lumbar epidural anaesthesia as antithrombotic prophylaxis in total hip replacement. Acta Chir Scand 151: 589–594

    Google Scholar 

  17. Korth R, Mongold HK, Muramatsu T, Zollner N (1985) Unsaturated 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indometacin, creatinephosphate/creatine phosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. Chem Phys Lipids 36: 209–214

    Google Scholar 

  18. Simonsen T, Nordøy A, Sjunneskog C, Lyngmo V (1988) The effect of cod liver oil in two populations with low and high intake of dietary fish. Acta Med Scand 223: 491–498

    Google Scholar 

  19. Brox JH, Killie J-E, Gunnes S, Nordøy A (1981) The effect of cod liver oil on platelets and vessel wall in man. Thromb Haemostas 46: 604–611

    Google Scholar 

  20. Sager G, Trovik T, Slørdal L, Jæger R, Prytz PS, Brox J, Reikerås O (1988) Catecholamine binding and concentrations in acute phase plasma after surgery. Scand J Clin Lab Invest 48: 419–424

    Google Scholar 

  21. Giddon DB, Lindhe J (1972) In vivo quantitation of local anestethetic suppression of leucocyte adherence. Am J Pathol 68: 327–338

    Google Scholar 

  22. Stewart GJ, Ritchie WGM, Lynch PR (1974) Venous endothelial damage produced by massive sticking and emigration of leucocytes. Am J Pathol 74: 507–532

    Google Scholar 

  23. Kjeldsen SE, Flaaten B, Eide I, Helgeland A, Leren P (1982) Evidence of increased peripheral catecholamine release in patients with long-standing, untreated essential hypertension. Scand J Clin Lab Invest 42: 217–223

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiology Section, Medical Department, University Hospital of Tromsø, N-9012, Tromsø, Norway

    R. F. Berntsen

  2. Department of Clinical Pharmacology and Toxicology, University Hospital of Tromsø, Tromsø, Norway

    T. Simonsen & H. Olsen

  3. Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Tromsø, Norway

    G. Sager

Authors
  1. R. F. Berntsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Simonsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Sager
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Olsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Berntsen, R.F., Simonsen, T., Sager, G. et al. Therapeutic lidocaine concentrations have no effect on blood platelet function and plasma catecholamine levels. Eur J Clin Pharmacol 43, 109–111 (1992). https://doi.org/10.1007/BF02280766

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02280766

Key words

Search

Navigation