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Effect of chronic treatment with enalapril on glucose tolerance and serum insulin in non-insulin-resistant Japanese patients with essential hypertension

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Summary

The effect of enalapril, an angiotensin converting enzyme inhibitor, on glucose tolerance and serum insulin response to a glucose load has been evaluated in 8 non-obese patients (3 women and 5 men) with untreated essential hypertension (WHO Stage I or II) and without insulin resistance. Following a 2-month run-in control period, each patient received oral enalapril 10 mg once daily for 6 months, and an intravenous glucose tolerance test (IVGTT) was performed at the end of the run-in control and active treatment periods.

Treatment with enalapril significantly lowered both the systolic and diastolic blood pressures. The response of plasma glucose to the IVGTT, glucose disappearance rate (k-value) and area under the serum insulin concentration time curve were comparable between the two phases.

The results suggest that long-term treatment with enalapril has no effect on glucose tolerance in non-obese, non-insulin-resistant patients with mild-to-moderate essential hypertension.

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Authors and Affiliations

  1. Division of Clinical Pharmacology, Clinical Research Institute, National Medical Center, Tokyo, Japan

    T. Baba & T. Ishizaki

  2. Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan

    T. Baba & T. Kodama

  3. Division of Internal Medicine, Hokushu-Chuo Hospital, Takanosu, Japan

    T. Kodama

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  3. T. Ishizaki
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Baba, T., Kodama, T. & Ishizaki, T. Effect of chronic treatment with enalapril on glucose tolerance and serum insulin in non-insulin-resistant Japanese patients with essential hypertension. Eur J Clin Pharmacol 45, 23–27 (1993). https://doi.org/10.1007/BF00315345

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