Summary
Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females).
Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators.
No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators).
Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women.
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Ladero, J.M., Andres, M.P., Bañares, A. et al. Acetylator polymorphism in rheumatoid arthritis. Eur J Clin Pharmacol 45, 279–281 (1993). https://doi.org/10.1007/BF00315397
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DOI: https://doi.org/10.1007/BF00315397