Summary
Iron deficiency is a common nutritional deficiency, which leads to structural functional and enzymatic changes in the body that may affect the pharmacokinetics of drugs.
The present study in 7 normal volunteers and 8 adult male patients with irondeficiency anaemia (IDA) was done to investigate the effect of iron deficiency and its treatment with total dose iron (TDI) on the bioavailability of a single dose of phenytoin. Phenytoin bioavailability was investigated before and 3 and 28 days after TDI.
The bioavailability parameters Cmax, tmax, AUC and 2 h phenytoin concentrations were not significantly different in anaemic patients as compared to normal volunteers before or after treatment, except for an increase in tmax 28 days after TDI treatment.
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Joshi, M.V., Pohujani, S.M., Mehta, B.C. et al. Effect of iron deficiency anaemia and its treatment on single dose phenytoin bioavailability. Eur J Clin Pharmacol 45, 387–388 (1993). https://doi.org/10.1007/BF00265961
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DOI: https://doi.org/10.1007/BF00265961