Summary
Although metrizamide is now being superseded by other contrast media, the mechanisms of its side effects may be of fundamental importance. One hundred and four consecutive patients with suspected cervical cord or root lesion were studied prospectively for factors which might influence the side effects of metrizamide myelography. Elderly patients were more prone to develop mental confusion. An earlier onset of dizziness and/or vertigo was associated with the lumbar route of intrathecal injection. Perhaps surprisingly, phenobarbitone prophylaxis shortened the duration of confusion and delayed the onset of headaches. Other factors, viz. sex, excess intracranial flow of metrizamide and myelographic blockage were not shown to have a significant influence on the adverse reactions.
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References
Hindmarsh T, Grepe A, Widen L (1975) Metrizamide-phenothiazine interaction. Acta Radiol [Diagn] 16:129–134
Amundsen P (1977) Metrizamide in cervical myelography. Acta Radiol [Suppl] 355:85–97
Skalpe IO (1977) Adverse effects of water soluble contrast media in myelography, cisternography and ventriculography: a review with special reference to metrizamide. Acta Radiol [Suppl] 355:359–370
Sackett JF, Strotter CM, Quaglieri CE, Javid MJ, Levin AB, Duff TA (1977) Metrizamide — CSF contrast medium. Radiology 123:779–782
Bastow M, Godwin-Austin RB (1979) Cervical myelopathy after metrizamide myelography. Br Med J 2:1262–1263
Paling MR, Quindlen EA, Di Chiro G (1980) Spinal seizures after metrizamide myelography in a patient with a spinal block. AJNR 1:473–474
Vincent FM, Zimmerman JE (1980) Metrizamide encephalopathy. Ann Neurol 7:494
Eldevik OP, Nakken KO, Haughton VM (1978) The effect of dehydration on the side effects of metrizamide myelography. Radiology 129:715–716
Nestvold K (1978) Kanyletykkelsens betydingn for besvaer etter spinalpunksjon. Tidsskr Nor Laegeforen 98:569
Gulati AN, Guadagnoll DA, Quigley JM (1981) Relationship of side effects to patient position during and after metrizamide lumbar myelography. Radiology 141:113–116
Sacks OW, Krohl MS, Messeloff CR, Schwartz WF (1972) Effects of levodopa in parkinsonian patients with dementia. Neurology 22:615–619
Sweet RD, McDowell FH, Feigenson JS, Loranger AW, Godell H (1976) Mental symptoms in Parkinson's disease during chronic treatment with levodopa. Neurology 26:305–310
Cronqvist S, Brismar J (1977) Cervical myelography with metrizamide. Acta Radiol [Suppl] 355:110–120
McCormick CC, ApSimon HT, Chakera TMH (1981) Myelography with metrizamide — an analysis of the complications encountered in cervical, thoracic and lumbar myelography. Aust NZ J Med 11:645–650
Kieffer SA, Binet EF, Esquerra JV, Hantman RP, Gross CE (1978) Contrast agents for myelography: clinical and radiologic evaluation of Amipaque and Pantopaque. Radiology 129: 695–705
Nickel AR, Salem JJ (1977) Clinical experience in North America with metrizamide. Evaluation of 1950 subarachnoid examinations. Acta Radiol [Suppl] 355:409–416
Sortland O (1977) Cervical myelography with metrizamide using lumbar injection. Acta Radiol [Suppl] 355:141–153
Sortland O, Lundervold A, Nesbakken R (1977) Mental confusion and epileptic seizures following cervical myelography with metrizamide. Acta Radiol [Suppl] 355:403–406
Weiss AD, Roberson GH, Brisman J, Davis KR, Ellis GT (1977) Metrizamide encephalography: the use of a new CSF soluble contrast agent (abstract). Neurology 27:388
Irstam L, Sellden U (1976) Adverse effects of lumbar myelography with Amipaque and Dimer-X. Acta Radiol [Diagn] 17: 145–159
Nielson H (1975) Epileptic seizures following cervical myelography. Neuroradiology 10:59–60
Ropper AH, Chiappa KH, Young RR (1979) The effect of metrizamide on the electrocephalogram: a prospective study in 61 patients. Ann Neurol 6:222–226
Hauge O, Falkenberg H (1982) Neuropsychologic reactions and other side effects after metrizamide myelography. AJR 139:357–360
Irstam L (1978) Lumbar myelography with Amipaque. Spine 3:70–82
Kaada B (1973) Transient EEG abnormalities following lumbar myelography with metrizamide. Acta Radiol [Suppl] 334: 380–386
Skalpe IO, Torbergsen T, Amundsen P, Presthus J (1973) Lumbar myelography with metrizamide. Acta Radiol [Suppl] 334: 367–379
Gelmers HJ (1981) Acute psycho-organic reactions after cervical myelography using metrizamide. Clin Neurol Neurosurg 83:57–61
Lamont AC, Zachary J, Sheldon PWE (1981) Cervical cord size in metrizamide myelography. Clin Radiol 32:409–412
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Yu, Y.L., du Boulay, G.H. & Paul, E. Influence of certain factors on the manifestations of the adverse effects of metrizamide myelography. Neuroradiology 28, 339–343 (1986). https://doi.org/10.1007/BF00333441
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DOI: https://doi.org/10.1007/BF00333441