Summary
The commonly used contrast medium metrizoate (isopaque Cerebral®) or the new nonionic iohexol were injected intravenously for enhancement of cranial CT in a randomized double blind study. Each group consisted of 105 patients. No serious reactions occurred. Ten patients receiving metrizoate had minor reactions of mainly allergic type, whereas only one patient receiving iohexol reacted. No differences in enhancement efficiency could be observed.
Similar content being viewed by others
References
Almen T, Boijsen E, Denneberg T, Golman K, Nilsson IM, Nosslin B (1979) Metrizamide in urography. Human pharmacology studies. Farmakoterapi (Oslo) 35:38–41
Kolbenstvedt A, Andrew E, Christophersen B, Golman K, Kvarstein B, Lien HH (1979) Metrizamide in high-dose urography. Acta Radiol Diagn 20:39–45
Almén T, Boijsen E, Lindell SE (1977) Metrizamide in angiography. I. Femoral angiography. Acta Radiol Diagn 18:33–38
Skalpe IO, Lundervold A, Tjörstad K (1977) Cerebral angiography with non-ionic (metrizamide) and ionic (meglumine metrizoate) watersoluble contrast media. A comparative study with double blind technique. Neuroradiology 14:15–19
Amundsen P, Dugstad G, Slettebö M (1978) Clinical testing of Amipaque for cerebral angiography. Neuroradiology 15: 89–93
Enge I, Nitter-Hauge S, Andrew E, Levorsad K (1977) Amipaque: a new contrast medium in coronary angiography. Report of a double-blind study in man. Radiology 125:317–322
Lindgren E (ed) (1980) Iohexol. A non-ionic contrast medium. Pharmacology and toxicology. Acta Radiol [Suppl] (Stockh) 362
Levorstad K, Kolbenstvedt A, Sommerfeld SC, Zachrisson BE, Jagenburg R, Egblad M, Thrane Nielsen N, Sjöberg S, Olbring J, Sveen K (1982) Tolerability and diagnostic usefulness of iohexol in human urography. An open multicentre study. (To be published in) Acta Radiol Diagn
Amundsen P, Dugstad G, Presthus J, Ahlgren P, Cronqvist S, Holtås S, Skalpe I, Lundervold A, Dahlström K, Renaa T (1982) Cerebral angiography with iohexol, a new non-ionic contrast medium. A Phase II multicentre clinical trial. (To be published in) Acta Radiol Diagn
Levorstad K, Simonsen S, Skrede M, Orning O, Tylén U, Olsson L, Selin K, Dahlström K, Andrew E (1982) Tolerability and diagnostic usefulness of iohexol in human cardioangiography. (To be published in) Acta Radiol Diagn
Holtås S (1982) A Phase III comparative clinical trial in cerebral angiography with iohexol 300 mg I/ml and Amipaque 300 mg I/ml. Nyegard, Stockholm
Sortland O, Nakstad P, Aaserud O, Lundervold A (1982) A randomized double-blind parallel study of iohexol 300 mg I/ml and Isopaque Cerebral 280 mg I/ml in cerebral angiography. Nyegaard, Stockholm
Hemmingsson A (1982) A double-blind cross-over study with iohexol 300 mg I/ml and Angiografin 306 mg I/ml in femoral angiography. Nyegaard, Stockholm
Selin K, Emanuelsson H, Renaa T (1982) Iohexol — a new nonionic contrast medium. Experiences in selective coronary arteriography. (To be published)
Nyman U, Nilsson P, Westergren A (1982) Pain and hemodynamic effects in aorto-femoral angiography. Clinical comparison of iohexol, ioxaglate and metrizamide. (Accepted for publication in) Acta Raidol Diagn
Mitzel W, Siefert H-M, Speck U (1980) Biochemical-pharmacological properties of iohexol. Acta Radiol Diagn [Suppl] (Stockh) 362:111–115
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Holtås, S., Cronqvist, S. & Renaa, T. Contrast enhanced brain CT comparison between iohexol and metrizoate. Neuroradiology 24, 213–215 (1983). https://doi.org/10.1007/BF00399773
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00399773