Summary
Acute disseminated encephalomyelitis (ADEM) is an uncommon inflammatory disorder of the nervous system. The appearance of ADEM on cranial CT scans has rarely been reported. The author reports seven cases in two instititions during a period of seven years. Only four of the seven patients had hypodense lesions in the white matter and six patients showed spotty, nodular, or gyral enhancement after contrast injections. The enhancement resolved with steroid therapy, leaving some persistent hypoattenuated areas even after 10 months follow-up, these findings support the dual components of the pathogenesis of ADEM. The vasculitic component may be responsive to steroids, nevertheless the demyelinating or necrotic areas may not, and the latter may be responsible for the sequelae of ADEM.
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References
Lukes SA, Norman D (1983) Computed tomography in acute disseminated encephalomyelitis. Ann Neurol 13:567–572
Pasternak JF, De Vivo DC, Prensky AL (1986) Steroid-responsive encephalomyelitis in childhood. Neurology 30: 481–486
Miller HG, Stanton JB, Gibbons JL (1951) Parainfectious encephalomyelitis and related syndromes. Q J Med 25: 427–505
Miller HG, Gibbson JL (1953) Acute disseminated encephalomyelitis and acute disseminated sclerosis. Results of treatment with ACTH. Br Med J 1345–1348
Van Bogaert L (1950) Postinfectious encephalomyelitis and multiple sclerosis. Neuropathol Exp Neurol 9:219–249
Russell DS (1956) The nosological unity of acute haemorrhagic leukoencephalitis and acute disseminated encephalomyelitis. Brain 78:369–379
Reik L Jr (1980) Disseminated vasculomyelinopathy: an immune complex disease. Ann Neurol 7:291–296
Hart MN, Earle KM (1975) Hemorrhagic and perivenous encephalitis: a clinico-pathological review of 38 cases. J Neurol Neurosurg Psychiatry 38:585–591
Spiller WG (1929) Encephalomyelitis disseminata. Arch Neurol Psychiatry 22:637
Ziegler DK (1966) Acute disseminated encephalitis. Arch Neurol 14:476–488
Poser CM (1979) Diseases of the myelin sheath. In: Baker AB, Baker LH (eds) Clinical neurology, vol 2. Harper & Row, Hagertown, pp 88–104
Okuno T, Fuseya Y, Ito M, Konishi Y, Nakano Y (1981) Reversible multiple hypodense areas in the white matter diagnosed as acute disseminated encephalomyelitis. Case report. J Comput Assist Tomogr 5 (1):119–121
Grinker RR, Bassoe P (1931) Disseminated encephalomyelitis: Correlation to other infections of the nervous system. Arch Neurol Psychiatry 25:723
Alvord EC Jr (1980) Acute disseminated encephalomyelitis and “allemic” neuroencephalopathies. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 9. American Elsevier, New York, pp 501–571
Johnson KP, Wolinsky JS, Ginsberg AM (1978) Immune mediated syndromes of the nervous system related to virus infection. In: Klawans HL (ed) Handbook of clinical neurology, vol 34, North-Holland, New York, pp 391–434
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This work has been in part presented on the 7th AOCN on September 1987, in Bali, Indonesia
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Thajeb, P., Chen, S.T. Cranial computed tomography in acute disseminated encephalomyelitis. Neuroradiology 31, 8–12 (1989). https://doi.org/10.1007/BF00342021
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DOI: https://doi.org/10.1007/BF00342021