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Measurement of caudate nucleus area —A more accurate measurement for Huntington's disease?

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Summary

Caudate nucleus atrophy occurs in Huntington's disease and methods of measuring this have been described using axial CT, but these are indirect and lack sensitivity. We measured caudate nucleus area (blind to the subjects' clinical state) in 30 subjects with or at risk of Huntington's disease, and in 100 normal age matched controls. Fifteen subjects with established symptomatic Huntington's disease, 3 with early symptoms, and 3 presymptomatic subjects (2 showing a high probability for the Huntington's disease gene on genetic testing, and one who has since developed symptoms) were correctly identified. Three normal (gene negative) family members were also correctly identified. Outcome is awaited in 6. CT caudate area measurement is simple and reproducible and we have found it to be a useful confirmatory test for Huntington's disease.

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References

  1. Hayden MR (1981) Huntington's chorea. Springer, Berlin Heidelberg New York

    Google Scholar 

  2. De la Monte SM, Vonsattel J-P, Richardson EP (1988) Morphometric demonstration of atrophic changes in the cerebral cortex, white matter and neostriatum in Huntington's disease. JNEP 47:516–525

    Google Scholar 

  3. Vonsattel J-P, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP (1985) Neuropathological classification of Huntington's disease. JNEP 44:559–577

    Google Scholar 

  4. Myers RH, Sax DS, Schoenfeld M, Bird ED, Wolf PA, Vonsattel J-P, White RF, Martin JB (1985) Late onset of Huntington's disease. JNNP 48:530–534

    Google Scholar 

  5. Smurl JF, Weaver DD (1987) Presymptomatic testing for Huntington chorea: guidelines for moral and social accountability. Am J Med Genet 26:247–257

    Google Scholar 

  6. Harper PS, Morris MJ (1989) Predictive testing for Huntington's disease. BMJ 298:404–405

    Google Scholar 

  7. Barr AM, Heinze WJ, Dobben GD, Valvassoni GE, Sugar O (1978) Bicaudate index in computerised tomography of Huntington disease and cerebral atrophy. Neurology 28:1196–1200

    Google Scholar 

  8. Stober T, Wussow W, Schimrigk K (1984) Bicaudate diameter-the most specific and simple CT parameter in the diagnosis of Huntington's disease. Neuroradiology 26:25–28

    Google Scholar 

  9. Starkstein SE, Folstein SE, Brandt J, Pearlson GD, McDonnell A, Folstein M (1989) Brain atrophy in Huntington's disease. Neuroradiology 31:156–159

    Google Scholar 

  10. Terrence CF, Delaney JF, Alberto MC (1977) Computed tomography for Huntington's disease. Neuroradiology 13:173–175

    Google Scholar 

  11. Sax S, Menzer L (1977) Computerised tomography in Huntington disease. Neurology 27:388

    Google Scholar 

  12. Shoulson I, Plassche W (1980) Huntington disease: the specificity of computed tomography measurements. Neurology 30:382–383

    Google Scholar 

  13. Neophytides AN, Chiro GD, Barron SA, Chase TN (1979) Computed axial tomography in Huntington's disease and persons at risk for Huntington's disease. Adv Neurol 23:185–191

    Google Scholar 

  14. Hayden MR, Hewitt J, Stoessl AJ, Clark C, Ammann W, Martin WRW (1987) The combined use of positron emission tomography and DNA polymorphism for preclinical detection of Hungtington's disease. Neurology 37:1441–1447

    Google Scholar 

  15. Berent S, Giordani B, Lehtinen S, Markel D, Penney JB, Buchtel HA, Starosta-Rubinstein S, Hichwa R, Young AB (1988) Positron emission tomographic scan investigations of Huntington's disease. Cerebral metabolic correlates of cognitive function. Ann Neurol 23:541–546

    Google Scholar 

  16. Simmons JT, Pastakia B, Chase TN, Shults CW (1986) Magnetic resonance imaging in Huntington's disease. AJNR 7:25–28

    Google Scholar 

  17. Nagel JS, Johnson KA, Ichise M, English RJ, Walshe TM, Morris JH, Holman BL (1988) Decreased 1123 IMP caudate nucleus uptake in patients with Huntington's disease. Clin Nuc Med 13: 486–490

    Google Scholar 

  18. Folstein SE, Jensen B, Leigh BJ, Folstein MF (1983) The measurement of abnormal movement: methods developed for Huntington's disease. Neurobehav. Toxicol Teratol 5:605–609

    Google Scholar 

  19. Stein RA, Pearce KI, Nosil J, Strecker TC (1985) Toward quantitative characterisation of the caudate nucleus through CT image enhancement. J CAT 9:708–714

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuroradiology, Western General Hospital, Edinburgh, Scotland

    R. J. Sellar

  2. Department of Radiology, Royal Infirmary, Lauriston Place, Edinburgh, Scotland

    J. M. Wardlaw & L. J. Abermethy

Authors
  1. J. M. Wardlaw
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  2. R. J. Sellar
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  3. L. J. Abermethy
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Wardlaw, J.M., Sellar, R.J. & Abermethy, L.J. Measurement of caudate nucleus area —A more accurate measurement for Huntington's disease?. Neuroradiology 33, 316–319 (1991). https://doi.org/10.1007/BF00587814

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  • DOI: https://doi.org/10.1007/BF00587814

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