Abstract
We have developed a new liquid material for embolisation of arteriovenous malformations: a mixture of methyl and butyl methacrylate, plus dimethylaminoethyl methacrylate copolymer (Eudragit-E) in a solvent consisting of ethanol and iopamidol. Upon contact with aqueous substances, Eudragit-E precipitates rapidly and forms a soft elastic sponge within 3 s, as the ethanol diffuses. In blood, the positively charged Eudragit-E aggregates the negatively charged blood elements. Transcatheter embolisation of 4 canine and 52 rat renal arteries was feasible. Histological studies revealed no acute inflammatory reaction within 1 week, but mild to moderate reactions in the subacute and chronic stages. No recanalisation was seen. Because of its unique properties and excellent thrombogenicity the Eudragit-E mixture seems a promising embolic material.
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Yamashita, K., Taki, W., Kikuchi, H. et al. A cationic polymer, Eudragit-E, as a new liquid embolic material for arteriovenous malformations. Neuroradiology 38 (Suppl 1), S151–S156 (1996). https://doi.org/10.1007/BF02278144
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DOI: https://doi.org/10.1007/BF02278144