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Reversible posterior leukoencephalopathy after combination chemotherapy

  • DIAGNOSTIC NEURORADIOLOGY
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Abstract

We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MRI findings. Diffusion-weighted images during the first days after the onset of symptoms predicted a small irreversible lesion in the frontal lobe, verified on T2-weighted images 1 month later. The patient showed full recovery after high-dose steroid treatment.

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Authors and Affiliations

  1. Department of Neurology and Rehabilitation, University of Tampere, 33521 Tampere, Finland, , , , , , FI

    J. Honkaniemi, M. Latvala, A. Hietaharju, J. Ollikainen, L. Vähämäki & H. Frey

  2. Department of Radiology, University of Tampere, 33521 Tampere, Finland, , , , , , FI

    V. Kähärä & P. Dastidar

  3. Department of Internal Medicine, University of Tampere, 33521 Tampere, Finland, , , , , , FI

    T. Salonen

  4. Department of Oncology, University of Tampere, 33521 Tampere, Finland, , , , , , FI

    L. Keskinen & P. Kellokumpu-Lehtinen

Authors
  1. J. Honkaniemi
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  2. V. Kähärä
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  3. P. Dastidar
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  4. M. Latvala
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  5. A. Hietaharju
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  6. T. Salonen
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  7. L. Keskinen
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  8. J. Ollikainen
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  9. L. Vähämäki
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  10. P. Kellokumpu-Lehtinen
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  11. H. Frey
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Additional information

Received: 4 April 2000/Accepted: 17 May 2000

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Honkaniemi, J., Kähärä, V., Dastidar, P. et al. Reversible posterior leukoencephalopathy after combination chemotherapy. Neuroradiology 42, 895–899 (2000). https://doi.org/10.1007/s002340000482

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  • DOI: https://doi.org/10.1007/s002340000482

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