Summary
The effect of intravesical administration of high dose recombinant tumor necrosis factor-α (rTNF) and in combination with systemic recombinant γ-interferon (rIFN) on murine bladder cancer was studied. RTNF was given at 12.5 μg/mouse on days 7, 11 and 15 after tumor instillation or at 2.5 μg/mouse on days 7, 9, 11, 13 and 15. Some groups were also injected i.v., 24-h prior to each rTNF treatment with rIFN at a dose of 1.3 μg/mouse. RTNF treatment suppressed tumor growth up to 48% of control, although the difference was not statistically significant. Combined administration of rIFN did not provide additional benefit.
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Balkwill FR, Lee A, Aldam G, Moodie E, Thomas JA, Tavernier J, Fiers W (1986) Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Cancer Res 46:3990
Fransen L, Vander Heyden J, Ruysschaert R, Fiers W (1986) Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell lines. Eur J Cancer Clin Oncol 22:419
Jain RK (1987) Transport of molecules in the tumor interstitium: a review. Cancer Res 47:3039
Lee K, Ewing JF, Sluss PM (1989) Effect of bacterial lipopolysaccaride on growth of murine bladder cancer, MBT-2. Urol Res 17:285
Lee K, O'Donnell RW, Schoen S, Cockett ATKC (1987) Effect of intravesical administration of tumor necrosis serum and human recombinant tumr necrosis factor on a murine bladder tumor. J Urol 138:430
O'Donnell RW, Laluppa JC, Lee K (1988) In vitro effect of tumor necrosis factor-alpha, interferon-gamma and macrophages on murine bladder tumor (MBT-2) cells. Proc Am Assoc Cancer Res 29:368 (Abstract 1464)
Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV (1984) Human tumor necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature 312:724
Schiller JH, Bitlner G, Storer B, Willson JK (1987) Synergistic antitumor effects of tumor necrosis factor and γ-interferon on colon carcinoma cell lines. Cancer Res 47:2809
Soloway MS (1977) Intravesical and systemic chemotherapy of murine bladder cancer. Cancer Res 17:2918
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Lee, K., O'Donnell, R.W. & Cockett, A.T.K. Influence of intravesical administration of tumor necrosis factor α and systemic γ-interferon on murine bladder cancer: Lack of dose response. Urol. Res. 18, 287–289 (1990). https://doi.org/10.1007/BF00294775
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DOI: https://doi.org/10.1007/BF00294775