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Possible advantages of aluminum-chloro-tetrasulfonated phthalocyanine over hematoporphyrin derivative as a photosensitizer in photodynamic therapy

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Abstract

The potency of aluminum-chloro-tetrasulfonated phthalocyanine (AlS4Pc) as a photosensitizer in photodynamic therapy was evaluated in in vitro and in vivo studies. Compared with hematoporphyrin derivative (HpD), the following advantages of AlS4Pc were revealed: (1) AlS4Pc was less toxic than HpD in vitro without hight irradiation. (2) AlS4Pc showed more photodynamic-dependent cytotoxicity and anti-tumor effect in the red area of the spectrum (>660 nm) at which tissue penetration is high. (3) AlS4Pc appeared to be removed more rapidly from normal tissues such as muscle and skin. (4) AlS4Pc showed less photodynamic-dependent cytotoxicity in vitro and milder cutaneous phototoxicity in vivo with UVA irradiation. On the basis of these observations, AlS4Pc shows considerable promise as a photosensitizer for PDT.

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References

  1. Bachor R, Flotte T, Scholz M, Dretler S, Hansan T (1992) Comparison of intravenous and intravesical administration of chloro-aluminum sulfonated phthalocyanine for photodynamic treatment in a rat bladder cancer model. J Urol 147:1404–1410

    Google Scholar 

  2. Chan WS, Svensen R, Phillips D, Hart IR (1986) Cell uptake, distribution and response to aluminum chloro-sulfonated phthalocyanine, a potential anti-tumor photosensitizer. Br J Cancer 53:255–263

    Google Scholar 

  3. Chan WS, Marshall J, Lam G, Hart IR (1988) Tissue uptake, distribution, and potency of the photoactivatable dye chloroaluminum sulfonated phthalocyanine in mice bearing transplantable tumors. Cancer Res 48:3040–3044

    Google Scholar 

  4. Chan WS, Marshall J, Hart IR (1989) Effect of tumour location on selective uptake and retention of phthalocyanines. Cancer Lett 44:73–77

    Google Scholar 

  5. Chan WS, Marshall J, Svensen R, Bedwell J, Hart IR (1990) Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminum phthalocyanine. Cancer Res 50:4533–4538

    Google Scholar 

  6. Evensen J, Sommer S, Moan J, Christensen T (1984) Tumorlocalizing and photosensitizing properties of the main components of hematoporphyrin derivative. Cancer Res 44:482–486

    Google Scholar 

  7. Gomer CJ, Dougherty TJ (1979) Determination of [3H] and [14C] hematoporphyrin derivative distribution in malignant and normal tissue. Cancer Res 39:146–151

    Google Scholar 

  8. Hisazumi H, Miyoshi N, Naito K, Misaki T (1984) Whole bladder wall photoradiation therapy for carcinoma in situ of the bladder: a preliminary report. J Urol 131:884–887

    Google Scholar 

  9. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63

    Google Scholar 

  10. Naito K, Hisazumi H, Uchibayshi T, Amano T, Hirata A, Komatsu K, Ishida T, Miyoshi N (1991) Integral laser photodynamic treatment of refractory multifocal bladder tumors. J Urol 146:1541–1545

    Google Scholar 

  11. Peng Q, Moan J, Farrants G, Danielsen HE, Rimington C (1991) Localization of potent photosensitizer in human tumor LOX by means of laser scanning microscopy. Cancer Lett 58:17–27

    Google Scholar 

  12. Pope A, MacRobert A, Phillips D, Bown SG (1991) The detection of phthalocyanine fluorescence in normal rat bladder wall using sensitive digital microscopy. Br J Cancer 64:875–879

    Google Scholar 

  13. Taya T, Kobayashi T, Tsukahara K, Uchibayashi T, Naito K, Hisazumi H, Kuroda K (1977) In vitro culture of malignant tumor tissues from the human urinary tract. Jpn J Urol 68:1003–1010

    Google Scholar 

  14. Tralau C, Young A, Walker N, Vernon DI, MacRobert AJ, Brown SB, Bown SG (1989) Mouse skin photosensitiviy with hematoporphyrin ether (DHE) and aluminum sulphonated phthalocyanine (AlSPc): a comparative study. Photochem Photobiol 49:305–312

    Google Scholar 

  15. Urano M, Nesumi N, Ando K, Koike S, Ohmura N (1976) Repair of potentially lethal radiation damage in acute and chronically hypoxic tumor cells in vivo. Radiology 118:447–451

    Google Scholar 

  16. Zalar G, Poh-Fitzpatrick M, Krohn D, Jacobs R, Harber LC (1977) Induction of drug photosensitization in man after parenteral exposure to hematoporphyrin. Arch Dermatol 113:1392–1397

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan

    K. Koshida, H. Hisazumi, K. Komatsu, A. Hirata & T. Uchibayashi

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  1. K. Koshida
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  2. H. Hisazumi
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  3. K. Komatsu
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  4. A. Hirata
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  5. T. Uchibayashi
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Koshida, K., Hisazumi, H., Komatsu, K. et al. Possible advantages of aluminum-chloro-tetrasulfonated phthalocyanine over hematoporphyrin derivative as a photosensitizer in photodynamic therapy. Urol. Res. 21, 283–288 (1993). https://doi.org/10.1007/BF00307712

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  • DOI: https://doi.org/10.1007/BF00307712

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