Abstract
Sixteen patients with abdominal neuroblastoma had 99m Technetium Phosphate Compounds (99m TC-PC) bone scans as a preoperative evaluation for metastatic disease. Ten patients (62%) had extraosseous tumor uptake while six patients (38%) did not. There was no difference in the incidence of tumor calcification, tumor necrosis or hydronephrosis in the two groups. However, VMA levels were significantly higher in the group with extraosseous tumor uptake. Various bone seeking radionuclides are compared to 99m TC-PC and possible mechanism for extraosseous uptake of such radionuclides are postulated. Awareness of the frequency of such uptake should reduce the possibility of errors in the interpretation of bone scans in patients with neuroblastoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Charkes, N. D., Valentine, G., Gravitz, B.: Interpretation of the normal 99m TC-polyphosphate rectilinear bone scan. Radiology107, 563 (1973)
Charkes, D. N., Young, I., Sklaroff, D. M.: The pathologic basis of the strontium bone scan. J.A.M.A.206, 2482 (1968)
Chaudhuri, T. K., Chaudhuri, T. K., Christie, J. J.: Tumor uptake of 99m TC-polyphosphate: Its similarity with 87m SR-citrate and dissimilarity with 67GA-citrate. J. Nucl. Med.15, 458 (1974)
Chaudhuri, T. K., Chaudhuri, T. K., Guleserian, H. P., Christie, J. H., Tonami, N.: Extraosseous noncalcified soft-tissue uptake of 99m TC-polyphosphate. J. Nucl. Med.15, 1054 (1974)
Fitzer, P. M.: 99m TC-polyphosphate concentration in neuroblastoma. J. Nucl. Med.15, 904 (1974)
Gilday, D. L., Ash, J. M., Reilly, B. J.: Radionuclide skeletal survey for pediatric neoplasms. Radiology123, 399 (1977)
Moes, C. A. F., Burrington, J. D.: The use of aortography in the diagnosis of abdominal masses in children. Radiology98, 59 (1971)
O'Mara, R. E., Brettner, A., Danigeles, J. A., Gould, V. L.: Fluorine-18 uptake within metastatic osteosarcoma of the liver. Radiology100, 113 (1971)
Pendergrass, H. P., Potsaid, M. S., Castronovo, F. P., Jr.: The clinical uses of 99m TC-diphosphonate (HEDSPA). Radiology107, 557 (1973)
Richards, A. G.: Metastatic calcification detected through scanning with 99m TC-polyphosphate. J. Nucl. Med.15, 1057 (1974)
Rosenfield, N., Treves, S.: Osseous and extraosseous uptake of 18f and 99m TC-polyphosphate in children with neuroblastoma. Radiology111,127 (1974)
Samuels, L. D.: 87m-Sr scans in children with extraosseous pathology. Am. J. Roentgenol. Radium Ther. Nucl. Med.109,813 (1970)
Samuels, L. D.: Detection and localization of extraskeletal malignant neoplasms of children with 87m strontium. Am. J. Roentgenol. Radium Ther. Nucl. Med.115, 777 (1972)
Samuels, L. D.: Skeletal scintigraphy in children. Semin. Nucl. Med.3, 89 (1973)
Silberstein, E. B., Saenger, E. L., Tofe, A. J., Alexander, G. W., Jr., Park, H. M.: Imaging of bone metastasis with 99m TC-SN-EHDP (diphosphonate), 18f and skeletal radiography. Radiology107, 551 (1973)
Subramanian, G., McAfee, J. G.: A new complex of 99m TC for skeletal imaging. Radiology99, 192 (1971)
Van Dyke, D., Anger, H. O., Yano, Y., Bozzini, C.: Bone blood flow shown with F-18 and the positron camera. Am. J. Physiol.209, 65 (1965)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Young, G., L'Heureux, P. Extraosseous tumor uptake of 99m Technetium Phosphate Compounds in children with abdominal neuroblastoma. Pediatr Radiol 7, 159–163 (1978). https://doi.org/10.1007/BF00975440
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00975440