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Ru-labeled ruthenocenoyl-glycine: comparison of clearance with hippuran

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Abstract

Ruthenocenoyl-glycine (ruppuran) is a metallocene analog of iodo-labeled hippuran. After injection of 103Ru-labeled ruppuran and ruthenocenoyl-1,1′-diglycine in rabbits, measurement with external detectors revealed a very rapid accumulation in the kidneys followed by rapid excretion of the 103Ru activity. By measurement of the radioactivity concentration in plasma and urine samples collected 1–60 min after IV injection, the plasma clearance was calculated and compared with the clearance of 125I-labeled hippuran injected simultaneously. The clearance of ruppuran and ruthenocenoyl-diglycine in rabbits was found to be somewhat higher than that of hippuran. Extrapolating to man (1.73 m3), plasma clearance with both ruthenocene derivatives was approximately 500–600 ml/min. Biochemical data as well as the nuclear properties of 97Ru indicate the usefulness of 97Ru-labeled ruthenocenoyl-glycine as a radiopharmaceutical for kidney function studies.

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Authors and Affiliations

  1. Pharmazeutisches Institut, Klinikum Steglitz, Freie Universität Berlin, Berlin, Germany

    Martin Wenzel Prof.Dr. & Gert Schachschneider

  2. Institut für Nuklearmedizin, Klinikum Steglitz, Freie Universität Berlin, Berlin, Germany

    Harald Meinhold

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  1. Martin Wenzel Prof.Dr.
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  2. Harald Meinhold
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  3. Gert Schachschneider
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Wenzel, M., Meinhold, H. & Schachschneider, G. Ru-labeled ruthenocenoyl-glycine: comparison of clearance with hippuran. Eur J Nucl Med 10, 138–142 (1985). https://doi.org/10.1007/BF00252722

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  • DOI: https://doi.org/10.1007/BF00252722

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