Abstract
Using positron emission tomography (PET) in combination with compounds labelled with positron-emitting radionuclides like 11C, 13N and 15O, it is possible to study metabolism in vivo in a non-invasive way. Nuclear magnetic resonance (NMR) imaging takes advantage of the spin of protons in water molecules to measure both their number and relaxation times in vivo, but is, in principle, not limited to protons and can also be used for other nuclei with a non-zero spin, e.g. 13C and 31P. The use of 13C opens the possibility of studying the metabolism of a large number of compounds. In order to choose the appropriate methodology for metabolic imaging, i.e. PET or NMR, it is important to know the sensitivity of each modality. The present study outlines the sensitivity of both techniques.
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Berger G, Maziere M, Prenant C, Sastre J, Comar D (1984) 11C Labelling of a protein: Concanavalin A. Int J Appl Radiat Isot 35:81–83
Bloch F, Hansen WW, Packard M (1946) Nuclear induction. Phys Rev 69:127
Bolster JM, Vaalburg W, van Veen W, van Dijk T, van der Molen HD, Wynberg H, Woldring MG (1983) Synthesis of no-carrier-added L- and D-[1-11C]-Dopa. Int J Appl Radiat Isot 34:1650–1652
Bottomley PA, Andrew ER (1978) RF magnetic field penetration, phase shift and power dissipation in biological tissue: Implications for NMR imaging. Phys Med Biol 23:630–643
Budinger TF, Gullberg GT, Huesman RH (1979) Emission computed tomography. In: Herman GT (ed) Image reconstructions from projections. Springer, Berlin Heidelberg New York, pp 147–242
Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171:1151–1153
Gadian DG (1982) Nuclear magnetic resonance and its application to living systems. Clarendon Press, Oxford
Korf J, Venema K (1983) Amino acids in substantia nigra of rats with striatal lesions produced by kainic acid. J Neurochem 40:1171–1173
Lauterbur PC (1973) Image formation by induced local interactions: Examples employing NMR. Nature 242:190–191
Purcell EM, Torrey HC, Pound HV (1946) Resonance absorption by nuclear magnetic moments in a solid. Phys Rev 69:37–38
Wolf AP (1981) Synthesis of organic compounds labeled, with positron emitters and the carrier problem. J Labelled Compd Radiopharm 18:1–2
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Paans, A.M.J., Vaalburg, W. & Woldring, M.G. A comparison of the sensitivity of PET and NMR for in vivo quantitative metabolic imaging. Eur J Nucl Med 11, 73–75 (1985). https://doi.org/10.1007/BF00252137
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DOI: https://doi.org/10.1007/BF00252137