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Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis-2-methoxyisobutylisonitriIe: a European multicentre study

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Abstract

In the context of a multicentre study on the use of technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi), we evaluated the accuracy of the ventricular function assessed at rest by means of first-pass radionuclide angiocardiography acquired during the injection of the tracer for myocardial perfusion scintigraphy. The results were compared with first-pass studies performed using reference tracers sodium pertechnetate Tc 99m or technetium 99m diethylene triamine penta-acetic acid or with gated radionuclide angiocardiography. A total of 66 patients of the 105 enrolled in the study could be evaluated. The comparison of the first-pass studies was possible in 33 subjects with regard to the left ventricular ejection fraction, yieldingr=0.909 (P< 10−6), and in 22 cases with regard to the right ventricular ejection fraction, yieldingr=0.712 (P<0.001). The comparison between the first-pass study using99mTc-Sestamibi and the equilibrium gated radionuclide angiocardiography was possible for the left ventricular ejection fraction in 26 cases, withr=0.937 (P<10−6), and for the right ventricular ejection fraction in 15 subjects, withr=0.783 (P<0.001). In conclusion, the assessment of ventricular function performed by acquiring a first-pass radionuclide angiocardiograph during the injection of99mTc-Sestamibi for perfusion myocardial scintigraphy can be considered reliable and accurate, when compared with the usually employed techniques. This result confirms the feasibility of a combined evaluation of perfusion and function at rest and during stress testing, which represents one of the most interesting advantages offered by the use of99mTc-Sestamibi.

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Authors and Affiliations

  1. Dipartimento di Fisiopathologia Clinica, Unità di Medicina Nucleare, Universitä di Firenze, Italy

    Gianni Bisi & Roberto Sciagrà

  2. Medizinische Fakultät der Rheinisch-Westfälischen Technischen Hochschule, Aachen, Germany

    Udalrich Büll

  3. Department of Nuclear Medicine, St. Bartholomew's Hospital, London, UK

    Keith E. Britton

  4. Luitpoldkrankenhaus, Würzburg, Germany

    Christoph Eilles

  5. Universitätsklinikum, Mainz, Germany

    Dagmar Eißner & Klaus Hahn

  6. Universitätsklinikum, Marburg, Germany

    Helmut Höffken & Klaus Joseph

  7. University Department of Medicine, Royal Infirmary, Glasgow, UK

    James H. McKillop

  8. Service de Médicine Nucléaire, Centre Hospitalier Universitaire Sart-Tilman, Tilman (Liege), Belgium

    Marie P. Larock & Pierre Rigo

  9. Universitätsklinikum, Essen, Germany

    Stefan P. Müller & Christoph Reiner

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  1. Gianni Bisi
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Bisi, G., Sciagrà, R., Büll, U. et al. Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis-2-methoxyisobutylisonitriIe: a European multicentre study. Eur J Nucl Med 18, 178–183 (1991). https://doi.org/10.1007/BF02262728

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  • DOI: https://doi.org/10.1007/BF02262728

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