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The ultrastructure of experimental arthrosis in dogs

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Summary

Experimental arthrosis was induced in previously healthy joints in a group of dogs by injection of fluid aspirated from another joint of the same animal previously damaged by trauma under sterile conditions.

Using electron microscopy progressive degenerative changes were observed at the surface of the joint, in the extracellular matrix, in the chondrocytes and in the pericellular band. The changes increased following serial injections of the joint fluid.

In another series, the joints were injected either with the centrifuged concentrate or the supernatant fluid and a comparison made of the contrasting effects upon the cellular and extracellular structures.

Résumé

Les auteurs ont réalisé une arthrose expérimentale chez le chien en injectant dans une articulation le liquide obtenu par ponction d'une autre articulation du même animal, dont le cartilage a été préalablement scarifié de façon aseptique.

L'examen des surfaces articulaires en microscopie électronique montre des altérations dégénératives progressives au niveau de la matrice extra-cellulaire, des chondrocytes et de la membrane péri-cellulaire. Ces modifications augmentent après des injections répétées de liquide synovial.

Dans une autre série d'animaux, on a injecté soit le culot de centrifugation, soit le surnageant et on a comparé les effets obtenus vis-à-vis des structures cellulaires et extra-cellulaires.

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References

  1. Dingle JT (1981) Catabolin, a cartilage catabolic factor from synovium. Clin Orthop 15: 219–231

    Google Scholar 

  2. Freeman MAR (1973) Adult articular cartilage. Pitman Medical, Oxford, pp 51–95

    Google Scholar 

  3. Ghadially FN, Roy S (1969) Ultrastructure of synovial joints in health and disease. Butterworths, London, pp. 68–70

    Google Scholar 

  4. Hulth A, Lindberg L, Telhag H (1970) Experimental osteoarthritis in rabbits. Preliminary report. Acta Orthop Scand 41: 522–530

    Google Scholar 

  5. Mankin HJ, Lippiello L (1970) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. J Bone Joint Surg 52: 424–434

    Google Scholar 

  6. Reimann J (1973) Experimental osteoarthritis of the knee rabbits induced by alterations of the load bearing. Acta Orthop Scand 44: 496–504

    Google Scholar 

  7. Rothwell AG, Bentley G (1973) Chondrocyte multiplication in osteoarthritic articular cartilage. J Bone Joint Surg 55: 588–594

    Google Scholar 

  8. Salter RJ, Field P (1960) The effects of continuous compression of living articular cartilage. J Bone Joint Surg 42: 31–49

    Google Scholar 

  9. Sledge CB, Blackburn MM (1968) Heparin, Dextran and Dextran Sulfate; effect — of lysosomes from embrionic cartilage. Calcif. Tissue Res 2: 65–68

    Google Scholar 

  10. Sokoloff L (1969) The biology of degenerative joint diseases. The University of Chicago Press, p 28

  11. Zamudio L, Contreras R, Medina FJ, López GR (1976) Producción experimental de — enfermedad articular degenerativa por medios — no mecánicos. Ann Orthop Traumatol 12: 157–166

    Google Scholar 

  12. Zamudio L, Garcí FG, Contreras R, Medina FJ, Smithers ME (1977) tNuevas investigaciones en la producción experimental de — enfermedad articular degenerativa por medios — no mecánicos. Acta Orthop Latino-Americana 4: 234–239

    Google Scholar 

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Zamudio, L., Palomo, A.M., García-Felix, G. et al. The ultrastructure of experimental arthrosis in dogs. International Orthopaedics 7, 215–221 (1984). https://doi.org/10.1007/BF00266830

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