Zusammenfassung
Es werden die Ergebnisse der autoradiographischen Bestimmung DNA-synthetisierender Lymphozyten (3H-Thymidin) bei 10 Patienten mit bakteriellen Infekten mit den Ergebnissen bei 10 gesunden Personen verglichen und den Resultaten bei 23 CLL-Patienten in verschiedenen Krankheitsstadien gegenübergestellt. Bei Patienten mit Infektionen lagen die Mittelwerte der T-Zellen niedriger, die der T-Zellen und Nicht-T-Zellen in der S-Phase höher als bei Normalen. Gegenüber Infektpatienten zeigen die CLL-Patienten früher Krankheitsstadien niedrigere S-Phase-T-Zellwerte und höhere S-Phase-Nicht-T-Zellwerte; im fortgeschrittenen Stadium sind alle DNA-synthetisierenden Lymphozyten vermehrt.
Summary
The results of autoradiographic determination of DNA-synthesizing lymphocytes (3H-thymidine) in 10 patients with bacterial infections were compared with results in 10 normal patients and contrasted with 23 CLL patients in different stages [12]. In patients with infectious diseases the absolute number of T cells was lower and the mean values of S-phase T cells and S-phase non-T cells was higher than in normal persons. In contrast to the patients with infections, CLL patients in stage 0–III have lower S-phase T cell values and higher S-phase non-T cell values. In stage IV, on the other hand, all DNA-synthesizing lymphocytes are increased.
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On the occasion of the 70th birthday and the retirement of Professor Dr. E. Havinga, Organic Chemistry, University of Leyden, The Netherlands
This work was supported by the Deutsche Forschungsgemeinschaft (Be 79/15)
Guest of the „Deutscher Akademischer Austauschdienst“
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van der Woerd-de Lange, J.A., Omran, N., Kaboth, W. et al. DNA-synthesizing T and non-T cells in bacterial infections. Blut 40, 151–155 (1980). https://doi.org/10.1007/BF01013698
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DOI: https://doi.org/10.1007/BF01013698