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Acute myelomonocytic leukemia with involvement of eosinophils and inversion of chromosome 16

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Summary

A case of acute nonlymphocytic leukemia (ANLL) with abnormal marrow eosinophils is presented. Thorough morphological, cytochemical, and cytogenetic studies confirm the existence of a recently defined new cytogeneticmorphological entity: acute myelomonocytic leukemia with abnormal bone marrow eosinophils (FAB M4), chloracetate esterase- and periodic acid-Schiffpositivity of eosinophilic granules, and pericentric inversion of chromosome 16, in this case combined with trisomy 8. So far 18 such cases have been reported from a single institution. The implications of this new association on the diagnosis of acute leukemia with abnormal eosinophils are discussed.

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References

  1. Anteunis A, Audebert AA, Krulik M, Debray J, Robineaux R (1978) Acute eosinophilic leukemia. Virchows Arch B Cell Pathol 27: 237–248

    CAS  PubMed  Google Scholar 

  2. Arthur DC, Bloomfield CD (1983) Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association. Blood 61: 994–998

    CAS  PubMed  Google Scholar 

  3. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukemias: French-American-British (FAB) Cooperative Group. Br J Haematol 33: 451–458

    Article  CAS  PubMed  Google Scholar 

  4. Benvenisti DS, Ultmann JE (1969) Eosinophilic leukemia. Ann Int Med 71: 731–745

    Article  CAS  PubMed  Google Scholar 

  5. Caspersson T, Zech L, Johansson C, Modest EJ (1970) Identification of human chromosomes by DNA-binding fluorescent agents. Chromosoma 30: 215–227

    Article  CAS  PubMed  Google Scholar 

  6. Drings P, Löffler H (1978) Anwendung wichtiger Färbeverfahren und zytochemischer Reaktionen. In: Queißer W (ed) Das Knochenmark. Thieme, Stuttgart, pp 11–18

    Google Scholar 

  7. Flandrin G, Daniel MT (1981) Cytochemistry in the classification of leukemias. In: Catovsky D (ed) The leukemic cell. Churchill Livingstone, Edinburgh London Melbourne New York, p 41

    Google Scholar 

  8. Gunz F, Baikie AG (1974) Leukemia, 3rd edn. Grune and Stratton, New York San Francisco London, pp 340–342

    Google Scholar 

  9. Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD (1983) Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Engl J Med 309: 630–636

    Article  PubMed  Google Scholar 

  10. Leder LD (1970) Akute myelo-monozytäre Leukämie mit atypischen Naphthol-AS-D-Chloracetat-Esterase-positiven Eosinophilen. Acta Haematol (Basel) 44: 52

    Article  CAS  PubMed  Google Scholar 

  11. Löffler H (1969) Cytochemische Klassifizierung der akuten Leukosen. In: Stacher A (ed) Chemo- und Immunotherapie der Leukosen und malignen Lymphome. Bohmann, Wien

    Google Scholar 

  12. Löffler H (1978) Eosinophilen-Leukämie. In: Stacher A, Höcker P (eds) Erkrankungen der Myelopoese. Urban and Schwarzenberg, München Berlin Wien, pp 407–412

    Google Scholar 

  13. Löffler H, Lück R, Syed Ali S (1975) Eosinophilenleukämie mit Chloracetat-Esterasepositiven Granula bei einem Kinde. Dtsch Med Wochenschr 41: 2092–2098

    Article  Google Scholar 

  14. Ruzicka F, Pawlowsky J, Erber A, Nowotny H (1976) Drei Fälle von Eosinophilenleukämie mit atypischer Granulation in Eosinophilen und Neutrophilen. Blut 32: 337–346

    Article  CAS  PubMed  Google Scholar 

  15. Schaefer HE, Hellriegel KP, Hennekeuser HH, Hübner G, Zach J, Fischer R, Gross R (1973) Eosinophilenleukämie, eine unreifzellige Myelose mit Chloroacetatesterase-positiver Eosinophilie. Blut 26: 7–19

    Article  CAS  PubMed  Google Scholar 

  16. Sjögren U (1976) Low mitotic activity in eosinophilic leukaemia. Acta Haematol 55: 153–159

    Article  PubMed  Google Scholar 

  17. Stavem P, Ly B, Blichfeldt P, Andreassen P (1978) Acute eosinophilo-myelomonocytic leukemia, one of the ‘in between leukemias’. Scand J Haematol 21: 355–359

    Article  CAS  PubMed  Google Scholar 

  18. Wintrobe MM (1981) Clinical hematology, 8th edn. Lea and Febiger, Philadelphia, pp 1557–1558

    Google Scholar 

  19. Wulfhekel U, Düllmann J, Bartels H, Hausmann K (1975) Zur Ultrastruktur und Cytochemie von eosinophil-myelomonocytären Leukämien. Virchows Arch A Pathol Anat Histol 365: 289–308

    Article  CAS  PubMed  Google Scholar 

  20. Yam LT, Li CY, Necheles TF, Katayama I (1972) Pseudoeosinophilia, eosinophilic endocarditis and eosinophilic leukemia. Am J Med 53: 193–202

    Article  CAS  PubMed  Google Scholar 

  21. Yunis JJ, Bloomfield CD, Ensrud K (1981) All patients with acute nonlymphocytic leukemia may have a chromosomal defect. N Engl J Med 305: 135–139

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. II. Medizinische Klinik und Poliklinik der Universität Kiel, Metzstr. 53, D-2300, Kiel, Federal Republic of Germany

    N. Schmitz, W. Gassmann & H. Löffler

  2. Abteilung Humangenetik der Universität Kiel, Schwanenweg 24, D-2300, Kiel, Federal Republic of Germany

    E. Gödde-Salz

Authors
  1. N. Schmitz
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  2. E. Gödde-Salz
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  3. W. Gassmann
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  4. H. Löffler
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Schmitz, N., Gödde-Salz, E., Gassmann, W. et al. Acute myelomonocytic leukemia with involvement of eosinophils and inversion of chromosome 16. Blut 48, 263–267 (1984). https://doi.org/10.1007/BF00320396

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