Skip to main content
SpringerLink
Log in

T-cell acute childhood lymphoblastic leukemia with chromosome 14q11 anomaly: a morphologic, immunologic, and cytogenetic analysis of 10 patients

  • Original Articles
  • Published:
Blut Aims and scope Submit manuscript

Summary

Ten patients with T-cell acute lymphoblastic leukemia (ALL) and a chromosome anomaly involving band 14q11 are described. Mitotic index of bone marrow blasts was high in all patients (average 3.0%). Lymphoid morphology of the leukemic blasts, however, varied somewhat among the patients. The leukemic cells of 5 patients showed an immunophenotypic profile corresponding to early or common thymic differentiation stages whereas 5 children showed strong expression of CD3 suggesting a more mature thymic phenotype. Leukemic karyotypes revealed a modal chromosome number of 46 in 9 cases, 92 in one case. A chromosome translocation t(11; 14) (p13; q11) was found in 5 cases, a t(1; 14) (p32; q11) in 2 cases, a t(10; 14) (q24; q11) in one case, a (hitherto undescribed) t(12; 14) (q22; q11) in one case, and an inv(14) (q11 q32) in one patient. Additional abnormalities were t(3; 10), t(7; 9), dup (7q), del (6q), del (10q), and del (1 q). Of 32 cases with T-cell ALL successfully karyotyped in our laboratory 15 (=47%) had structural aberrations involving chromosomes 1, 3, 6, 7, 9, 10, 12, 14. Ten of these 15 patients (=67%) had a chromosome 14q11 anomaly. It is concluded that chromosome band 14q11, the gene locus of the T-cell receptor α-chain, is the most common site for structural chromosome aberrations in T-cell ALL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baer R, Chen K-C, Smith SD, Rabitts TH (1985) Fusion of an immunoglobulin variable gene and a T-cell receptor constant gene in the chromosome 14 inversion associated with T-cell tumours. Cell 43: 705–713

    Google Scholar 

  2. Clare N, Boldt D, Messerschmidt G, Zeltzer P, Hansen K, Manhoff L (1986) Lymphocyte malignancy and chromosome 14: Structural aberrations involving band q 11. Blood 67: 704–709

    Google Scholar 

  3. Croce CM, Isobe M, Palumbo A, Puck J, Ming J, Tweardy D, Erikson J, Davis M, Rovera G (1985) Gene for α-chain of human T-cell receptor: Location on chromosome 14 region involved in T-cell neoplasms. Science 227: 1044–1047

    Google Scholar 

  4. Denny CT, Hollis GF, Hecht F, Morgan R, Link MP, Smith SD, Kirsch IR (1986) Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development. Science 234: 197–200

    Google Scholar 

  5. Dubé ID, Raimondi SC, Pi D, Kalousek DK (1986) A new translocation, t(10;14) (q24;q11), in T cell neoplasia. Blood 67: 1181–1184

    Google Scholar 

  6. First MIC Cooperative Study Group (1986) Morphologic, immunologic, and cytogenetic (MIC) working classification of acute lymphoblastic leukemias. Cancer Genet Cytogenet 23: 189–197

    Google Scholar 

  7. Furley AJ, Mizutani S, Weilbaecher K, Dhaliwal HS, Ford AM, Chan LC, Molgaard HV, Toyonaga B, Mak T, van den Elsen P, Gold D, Terhorst C, Greaves MF (1986) Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T 3 complex. Cell 46: 75–87

    Google Scholar 

  8. González-Sarmiento R, LeBien TW, Bradley JG, Greenberg JM, Seidman JG, Ang S, Kersey JH (1987) Acute leukemia expressing the gamma gene product of the putative second T cell receptor. J Clin Invest 79: 1281–1284

    Google Scholar 

  9. Harbott J, Engel R, Gerein V, Schwamborn D, Rudolph R, Lampert F (1986) (11;14) translocation in three boys with acute lymphoblastic leukemia of T-cell immunophenotype. Blut 52: 45–50

    Google Scholar 

  10. Henze G, Buchmann S, Fengler R, Hartmann R (1987) The BFM relapse studies in childhood ALL. Concepts of two multicenter trials and results after 2 1/2 years. Haematol Blood Transfusion 30: 147–155

    Google Scholar 

  11. Hiddemann W, Ludwig WD, Herrmann F, Harbott J, Beck JD, Lampert F, Odenwald E, Riehm H (1986) New techniques in the diagnosis and pretherapeutic characterization of acute leukemias in children: Analyses by flow cytometry, immunology and cytogenetics in the BFM studies. Monogr Paediatr 18: 106–127

    Google Scholar 

  12. Hossfeld DK (1987) Chromosomes in acute lymphocytic leukemia. Cancer Genet Cytogenet 26: 59–64

    Google Scholar 

  13. Janka GE, Winkler K, Jürgens H, Göbel U, Gutjahr P, Spaar HJ (1986) Akute lymphoblastische Leukämie im Kindesalter: Die COALL-Studien. Klin Pädiatr 198: 171–177

    Google Scholar 

  14. Kagan J, Finan J, Letofsky J, Besa EC, Nowell PC, Croce CM (1987) α-chain locus of the T-cell antigen receptor is involved in the t(10; 14) chromosome translocation of T-cell acute lymphocytic leukemia. Proc Natl Acad Sci USA 84: 4543–4546

    Google Scholar 

  15. Le Beau MM, Diaz MO, Rowley JD, Mak TW (1985) Chromosomal localization of the human T cell receptor β-chain genes. Cell 41: 335

    Google Scholar 

  16. Le Beau MM, McKeithan TW, Shima EA, Goldman-Leukin RE, Chan SJ, Bell GI, Rowley JD, Diaz MO (1986) T-cell receptor α-chain gene is split in a human T-cell leukemia cell line with a t(11; 14) (p 15; q 11). Proc Natl Acad Sci USA 83: 9744–9748

    Google Scholar 

  17. Lewis WH, Michalopoulos EE, Williams DL, Minden MD, Mak TW (1985) Breakpoints in the human T-cell antigen receptor α-chain locus in two T-cell leukaemia patients with chromosomal translocations. Nature (London) 317: 544–546

    Google Scholar 

  18. Mathieu-Mahul D, Bernheim A, Sigaux F, Daniel M-T, Larsen L-J, Berger R (1986) Translocation t(1; 14) et remaniement du gène de la chaîne alpha du récepteur T dans une leucémie aigue lymphoblastique T. CR Acad Sci Paris 302: 525–528

    Google Scholar 

  19. Mirro J, Kitchingman G, Behm FG, Murphy SB, Goorha RM (1987) T cell differentiation stages identified by molecular and immunologic analysis of the T cell receptor complex in childhood lymphoblastic leukemia. Blood 69: 908–912

    Google Scholar 

  20. Murre C, Waldmann RA, Morton CC, Bongiovanni KF, Waldmann TA, Shows TB, Seidman JG (1985) Human γ-chain genes are rearranged in leukemic T cells and map to the short arm of chromosome 7. Nature (London) 316: 549–552

    Google Scholar 

  21. Pinkel D (1987) Curing children of leukemia. Cancer 59: 1683–1691

    Google Scholar 

  22. Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (1985) The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. EMBO J 4: 1461–1465

    Google Scholar 

  23. Riehm H, Feickert H-J, Lampert F (1986) Acute lymphoblastic leukaemia. In: Voûte PA et al. (eds) Cancer in children. Springer, Berlin Heidelberg New York Tokyo, pp 101–118

    Google Scholar 

  24. Sadamori N, Nishino K, Kusano M, Tomonaga Y, Tagawa M, Yao E-I, Sasagawa I, Nakamura H, Ichimaru M (1986) Significance of chromosome 14 anomaly at band 14q11 in Japanese patients with adult T-cell leukemia. Cancer 58: 2244–2250

    Google Scholar 

  25. Williams DL, Look AT, Melvin SL, Roberson PK, Dahl G, Flake T, Stass S (1984) New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia. Cell 36: 101–109

    Google Scholar 

  26. Yunis JJ, Bloomfield CD, Ensrud K (1981) All patients with acute non-lymphocytic leukemia may have a chromosomal defect. N Engl J Med 305: 135–139

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kinderpoliklinik, Universität Giessen, Feulgenstrasse 12, D-6300, Giessen, Federal Republic of Germany

    F. Lampert, J. Harbott & J. Ritterbach

  2. Medizinische Klinik, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    W.-D. Ludwig

  3. Institut für Humangenetik, Universität Lübeck, Ratzeburger Allee 160, D-2400, Lübeck, Federal Republic of Germany

    C. Fonatsch

  4. Kinderlinik, Universität Düsseldorf, Moorenstrasse 5, D-4000, Düsseldorf 1, Federal Republic of Germany

    D. Schwamborn

  5. Kinderklinik, Universität Tübingen, Rümelinstrasse 23, D-7400, Tübingen, Federal Republic of Germany

    B. Stier

  6. 1. Kinderklinik, KZVA, Stenglinstrasse, D-8900, Augsburg, Federal Republic of Germany

    A. Gnekow

  7. Kinderklinik, Universität Frankfurt, Theodor-Stern-Kai 7, D-6000, Frankfurt 70, Federal Republic of Germany

    V. Gerein

  8. Kinderklinik, Universität Essen, Hufelandstrasse 55, D-4300, Essen, Federal Republic of Germany

    B. Stollmann

  9. Kinderklinik, Universität Freiburg, Mathildenstrasse 1, D-7800, Freiburg, Federal Republic of Germany

    A. Jobke

  10. Kinderklinik, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    G. Janka-Schaub

Authors
  1. F. Lampert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Harbott
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Ritterbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W.-D. Ludwig
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Fonatsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. Schwamborn
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B. Stier
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. Gnekow
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. V. Gerein
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. B. Stollmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. A. Jobke
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. G. Janka-Schaub
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lampert, F., Harbott, J., Ritterbach, J. et al. T-cell acute childhood lymphoblastic leukemia with chromosome 14q11 anomaly: a morphologic, immunologic, and cytogenetic analysis of 10 patients. Blut 56, 117–123 (1988). https://doi.org/10.1007/BF00320016

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00320016

Key words

Search

Navigation