Summary
The authors present the case of a 20-yearold woman who developed a peripheral neuroectodermal neoplasm of the thoracopulmonary region (Askin tumor) 7 years after achieving complete remission of stage-IV Hodgkin's disease. The previous treatment had consisted of eight courses of alternating MOPP/ ABVD combined with involved-field 20-Gy radiotherapy. The second neoplasm appeared in a nonirradiated area of the chest wall, with erosion of the ribs as shown by sonography and computed tomography. The histological pattern was in accordance with a generic diagnosis of a malignant small cell tumor; the immunostaining positivity of the neoplastic cells for the neuron-specific enolase allowed us to make the diagnosis of a tumor with a neuroectodermal origin. Partial resection of the neoplasm and four courses of chemotherapy including adriamycin, cisplatin, and ifosfamide induced a complete remission, confirmed by surgical restaging. She is alive and well 10 months after the completion of therapy. The clinical, radiological, and microscopic features of this tumor occurring as a secondary neoplasm after Hodgkin's disease are described.
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Askin FB, Rosai J, Sibley RK, Dehner LP, Mc Alister WH (1979) Malignant small cell tumor of the thoracopulmonary region in childhood. A distinctive clinicopathologic entity. Cancer 43:2438–2451
Boockman MA, Longo DL (1986) Concomitant illness in patients treated for Hodgkin's disease. Cancer Treat Rev 13:77–111
Dehner LP (1986) Peripheral and central primitive neuroectodermal tumors. A nosologic concept seeking a consensus. Arch Pathol Lab Med 110:997–1005
Gerald WL, Miller HK, Battifora H, Miettinen M, Silva EG, Rosai J (1991) Intra-abdominal desmoplastic small round-cell tumor. Am J Surg Pathol 15:499–513
Halperin EC, Greenberg MS, Suit HD (1984) Sarcoma of bone and soft tissue following treatment of Hodgkin's disease. Cancer 53:232–236
Jurgens H, Verena B, Harms D, Beck J, Brandeis W, Etspuler G, Gadner H, Schmidt D, Treuner J, Winkler K, Gobel U (1988) Malignant peripheral neuroectodermal tumors. A retrospective analysis of 42 patients. Cancer 61:349–357
Krikorian JG, Burke, Rosemberg SA, Kaplan HS (1979) Occurrence of non-Hodgkin's lymphomas after therapy for Hodgkin's disease. N Engl J Med 300:452–458
Tester WJ, Kinsella TJ, Waller B (1984) Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience. J Clin Oncol 2:762–769
Tucker MA, Coleman CN, Cox RS, Varghese A, Rosemberg SA (1988) Risk of second cancers after treatment for Hodgkin's disease. N Engl J Med 318:76–81
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Anselmo, A.P., Cartoni, C., Pacchiarotti, A. et al. Peripheral neuroectodermal tumor of the chest (Askin tumor) as secondary neoplasm after Hodgkin's disease: A case report. Ann Hematol 68, 311–313 (1994). https://doi.org/10.1007/BF01695039
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DOI: https://doi.org/10.1007/BF01695039