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Molecular pathology of AIDS-related lymphomas

Biologic aspects and clinicopathologic heterogeneity

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Summary

A high frequency of lymphoma in human immunodeficiency virus-infected individuals has been reported since the outbreak of the acquired immunodeficiency syndrome (AIDS) epidemic in 1982. AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) is almost invariably derived from B cells and is classified as high- or intermediate-grade NHL, according to the working formulation. Two main histologic types are recognized, including small noncleaved cell lymphoma (SNCCL) and diffuse large cell lymphoma (DLCL). Pre-existing host factors putatively involved in lymphoma development include disrupted immunosurveillance, deregulated cytokine production, chronic antigen stimulation, and infection by Epstein-Barr virus (EBV). These alterations are associated with the development of multiple oligoclonal expansions which correspond to the clinical phase known as persistent generalized lymphadenopathy (PGL). The appearance of a true AIDS-NHL is characterized by the presence of a monoclonal B-cell population displaying several genetic lesions, including monoclonal EBV infection, c-MYC and BCL-6 rearrangements, RAS mutations, p53 inactivation, and 6q deletions. These genetic lesions cluster into two distinct molecular pathways, which specifically associate with the different histologic subtypes of AIDS-NHL, i.e., AIDS-SNCCL and AIDS-DLCL. The presence of distinct genetic pathways for AIDS-SNCCL and AIDS-DLCL correlate with a number of clinical features which distinguish these two groups of tumors, including differences in the age of onset, CD4 counts at the time of presentation, time elapsed since HIV infection, and clinical outcome.

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References

  1. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533–538

    PubMed  Google Scholar 

  2. Ballerini P, Gaidano G, Gong JZ, Tassi V, Saglio G, Knowles DM, Dalla-Favera R (1993) Multiple genetic lesions in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Blood 81:166–176

    PubMed  Google Scholar 

  3. Benjamin D, Knobloch TJ, Dayton MA (1992) Human B-cell interleukin-10:B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin 10. Blood 80:1289–1298

    PubMed  Google Scholar 

  4. Beral V, Petterman T, Berkelman R, Jaffe H (1991) AIDS-associated non-Hodgkin lymphoma. Lancet 337:805–809

    PubMed  Google Scholar 

  5. Birx DL, Redfield RR, Tosato G (1986) Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N Engl J Med 314:874–879

    PubMed  Google Scholar 

  6. Birx DL, Redfield RR, Tencer K, Fowler A, Burke DS, Tosato G (1990) Induction of interleukin-6 during human immunodeficiency virus infection. Blood 76:2303–2310

    PubMed  Google Scholar 

  7. Borisch-Chappuis B, Nezelof C, Muller H, Muller-Hermelink HK (1990) Different Epstein-Barr virus expression in lymphomas from immunocompromised and immunocompetent patients. Am J Pathol 136:751–758

    PubMed  Google Scholar 

  8. Boyle MJ, Sewell WA, Sculley TB, Apolloni A, Turner JJ, Swanson CE, Penny R, Cooper DA (1991) Subtypes of Epstein-Barr virus in human immunodeficiency virus-associated non-Hodgkin lymphoma. Blood 78:3004–3011

    PubMed  Google Scholar 

  9. Carbone A, Tirelli U, Vaccher E, Volpe R, Gloghini A, Bertola G, De Re V, Rossi C, Boiocchi M, Monfardini S (1991) A clinicopathologic study of lymphoid neoplasias associated with human immunodeficiency virus infection in Italy. Cancer 68:842–852

    PubMed  Google Scholar 

  10. Carbone A, Tirelli U, Gloghini A, Volpe R, Boiocchi M (1993) Human immunodeficiency-virus-associated systemic lymphomas may be subdivided into two main groups according to Epstein-Barr viral latent gene expression. J Clin Oncol 11:1674–1681

    PubMed  Google Scholar 

  11. Center for Disease Control (1985) Revision of the case definition of acquired immunodeficiency syndrome for national reporting — United States. Ann Intern Med 103:402–408

    Google Scholar 

  12. Chadburn A, Cesarman E, Jagirdar J, Subar M, Mir RN, Knowles DM (1993) CD30 (Ki-1)-positive anaplastic large cell lymphomas in individuals infected with the human immunodeficiency virus. Cancer 72:3078–3090

    PubMed  Google Scholar 

  13. Chaganti RS, Jhanwar SC, Koziner B, Arlin Z, Mertelsmann R, Clarkson B (1983) Specific translocations characterize Burkitt's-like lymphoma of homosexual men with the acquired immunodeficiency syndrome. Blood 61:1265–1268

    PubMed  Google Scholar 

  14. Cleary ML, Nalesnik MA, Shearer WT, Sklar J (1988) Clonal analysis of transplant-associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus. Blood 72:349–352

    PubMed  Google Scholar 

  15. Contreras-Bodin BA, Anvret M, Imreh S, Altiok E, Klein G, Masucci MG (1991) B-cell phenotype-dependent expression of the Epstein-Barr virus nuclear antigens EBNA-2 to EBNA-6: studies with somatic cell hybrids. J Gen Virol 72:3025–3033

    PubMed  Google Scholar 

  16. Dalla-Favera R (1992) Chromosomal translocations involving the c-myc oncogene in lymphoid neoplasia. In: Kirsch IR (ed) The causes and consequences of chromosomal aberrations. CRC Press, Boca Raton, pp 313–332

    Google Scholar 

  17. Emilie D, Coumbaras J, Raphael M, Devergne O, Delecluse HJ, Gisselbrecht C, Michelis JF, Van Damme J, Taga T, Kishimoto T, Crevon MC, Galanaud P (1992) Interleukin-6 production in high-grade B lymphomas: correlation with the presence of malignant immunoblasts in acquired immunodeficiency syndrome and in human immunodeficiency virus-seronegative patients. Blood 80:498–504

    PubMed  Google Scholar 

  18. Editorial (1991) Epstein-Barr virus and AIDS-associated lymphomas. Lancet 338:979–981

  19. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–767

    PubMed  Google Scholar 

  20. Feichtinger H, Rutkonen P, Parravicini C, Su-Ling L, Kaaya EE, Bottiger D, Biberfeld G, Biberfeld P (1990) Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus. Am J Pathol 137:1311–1315

    PubMed  Google Scholar 

  21. Frizzera G, Rosai J, Dehner LP, Spector BA, Kersey JH (1980) Lymphoreticular disorders in primary immunodeficiency: new finding based on an updated histologic classification of 35 cases. Cancer 46:692–699

    PubMed  Google Scholar 

  22. Frizzera G (1992) Atypical lymphoproliferative disorders. In: Knowles DM (ed) Neoplastic hematopathology. Williams & Wilkins, Baltimore, pp 459–495

    Google Scholar 

  23. Gaidano G, Dalla-Favera R (1992) Proto-oncogenes and tumor suppressor genes. In: Knowles DM (ed) Neoplastic hematopathology. Williams & Wilkins, Baltimore, pp 245–261

    Google Scholar 

  24. Gaidano G, Dalla-Favera R (1992) Biologic aspects of human immunodeficiency virus-related lymphoma. Curr Opinion Oncol 4:900–906

    Google Scholar 

  25. Gaidano G, Parsa NZ, Tassi V, Della-Latta P, Chaganti RSK, Knowles DM, Dalla-Favera R (1993) In vitro establishment of AIDS-related lymphoma cell lines: phenotypic characterization, oncogene and tumor suppressor gene lesions, and heterogeneity in Epstein-Barr virus infection. Leukemia 7:1621–1629

    PubMed  Google Scholar 

  26. Gaidano G, Ballerini P, Gong JZ, Inghirami G, Neri A, Newcomb EW, Magrath IT, Knowles DM, Dalla-Favera R (1991) p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 88:5413–5417

    PubMed  Google Scholar 

  27. Gaidano G, Lo Coco F, Ye BH, Shibata D, Levine AM, Knowles DM, Dalla-Favera R (1994) Rearrangements of the BCL-6 gene in AIDS-associated non-Hodgkin lymphoma: association with diffuse large-cell subtype. Blood 84:397–402

    PubMed  Google Scholar 

  28. Gaidano G, Hauptschein RS, Parsa NZ, Offit K, Rao PH, Lenoir G, Knowles DM, Chaganti RSK, Dalla-Favera R (1992) Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma. Blood 80:1781–1787

    PubMed  Google Scholar 

  29. Gaidano G, Hauptschein RS, Venkatraj VS, Rutner T, Rao PH, Offit K, Chaganti RSK, Dalla-Favera R (1994) 6q Deletions in B-cell non-Hodgkin lymphoma. In: Borden EC, Goldman JM, Grignani F (eds) Molecular diagnosis and mon-itoring of leukemia and lymphoma. Ares-Serono Publications, Rome, pp 9–19

    Google Scholar 

  30. Gail MH, Pluda JM, Rabkin CS, Biggar RJ, Goedert JJ, Horm JW, Sondik EJ, Yarchoan R, Broder S (1991) Projection of the incidence of non-Hodgkin's lymphoma related to acquired immunodeficiency syndrome. J Natl Cancer Inst 83:695–700

    PubMed  Google Scholar 

  31. Goldschmidts WL, Bhatia K, Franklin Johnson J, Akar N, Gitierrez MI, Shibata D, Carolan M, Levine A, Magrath IT (1992) Epstein-Barr virus genotypes in AIDS-associated lymphomas are similar to those in endemic Burkitt lymphoma. Leukemia 6:875–878

    PubMed  Google Scholar 

  32. Groopman JE, Sullivan JL, Mulder C, Ginsburg D, Orkin SH, O'Hara CJ, Falchuk K, Wong-Staal F, Gallo RC (1986) Pathogenesis of B-cell lymphoma in a patient with AIDS. Blood 67:612–615

    PubMed  Google Scholar 

  33. Haluska FG, Russo G, Kant J, Andreef M, Croce CM (1989) Molecular resemblance of an AIDS-associated lymphoma and endemic Burkitt lymphomas: implications for their pathogenesis. Proc Natl Acad Sci USA 86:8907–8911

    PubMed  Google Scholar 

  34. Hamilton-Dutoit SJ, Pallesen J, Franzmann MB, Karkov J, Black F, Skinhøj P, Pedersen C (1991) AIDS-related lymphoma: histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization. Am J Pathol 138:149–163

    PubMed  Google Scholar 

  35. Hamilton-Dutoit SJ, Delecluse HJ, Raphael M, Lenoir G, Pallesen G (1991) Detection of Epstein-Barr virus genomes in AIDS-related lymphomas: sensitivity and specificity of in situ hybridization compared with Southern blotting. J Clin Pathol 44:686–690

    Google Scholar 

  36. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary M, Delsol G, de Wolf-Peelers C, Falini B, Gatter KC, Grogan TM, Isaacson PC, Knowles DM, Mason DY, Muller-Harmelink H-K, Pileri SA, Piris MA, Ralfkiaer E, Wamke RA (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood (in press)

  37. Ho M, Miller G, Atchison RW, Breinig MK, Andiman W, Starzl TE, Eastman R, Griffith BP, Hardesty RL, Bahnson HT, Hakala TR, Rosenthal JT (1985) Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: the role of primary infection. J Infect Dis 152:876–886

    PubMed  Google Scholar 

  38. Hoover R, Fraumeni JF jr (1973) Risk of cancer in renal transplant recipients. Lancet 2:55–57

    PubMed  Google Scholar 

  39. Karp JE, Broder S (1991) Acquired immunodeficiency syndrome and non-Hodgkin's lymphomas. Cancer Res 51:4743–4756

    PubMed  Google Scholar 

  40. Kerckaert J-P, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C (1993) LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphoma. Nature Genet 5:66–69

    PubMed  Google Scholar 

  41. Kieff E, Leibowitz D (1989) Onocogenesis by herpes viruses. In: Weinberg RA (ed) Oncogenes and the molecular origins of cancer. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 259–280

    Google Scholar 

  42. Klein G (1992) Epstein-Barr virus-carrying cells in Hodgkin's disease. Blood 80:299–300

    PubMed  Google Scholar 

  43. Knowles DM, Chamulak GA, Subar M, Burke JS, Dugan M, Wenz J, Slywotzky C, Pelicci P-G, Dalla-Favera R, Raphael B (1988) Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 108:744–753

    PubMed  Google Scholar 

  44. Knowles DM, Inghirami G, Ubriaco A, Dalla-Favera R (1989) Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 73:792–799

    PubMed  Google Scholar 

  45. Levine AM, Sullivan-Halley J, Pike MC, Rarick MU, Loureiro C, Bernstein-Singer M, Willson E, Brynes R, Parker J, Rasheed S, Gill PS (1991) Human immunodeficiency virus-related lymphoma: prognostic factors predictive of survival. Cancer 68:2466–2472

    PubMed  Google Scholar 

  46. Levine AM (1992) Acquired immunodeficiency syndrome-related lymphoma. Blood 80:8–20

    PubMed  Google Scholar 

  47. Lo Coco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM, Chaganti RSK, Dalla-Favera R (1994) Rearrangements of the BCL-6 gene in diffuse large-cell non-Hodgkin lymphoma. Blood 83:1757–1759.

    PubMed  Google Scholar 

  48. Locker J, Nalesnik M (1989) Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol 135:977–987

    PubMed  Google Scholar 

  49. Lombardi L, Newcomb EW, Dafla-Favera R (1987) Pathogenesis of Burkitt's lymphoma: expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human lymphoblasts. Cen 49:161–170

    Google Scholar 

  50. MacMahon EME, Glass JD, Hayward SD, Mann RB, Becker PS, Charache P, McArthur JC, Ambinder RF (1991) Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet 338:969–973

    PubMed  Google Scholar 

  51. McDunn SH, Winter JN, Variakojis D, Rademaker AW, Von Roenn JH, Tollman MS, Gordon LI, Bauer KD (1991) Human immunodeficiency virus-related lymphomas: a possible association between tumor proliferation, lack of ploidy anomalies, and immune deficiency. J Clin Oncol 9:1334–1340

    PubMed  Google Scholar 

  52. McManaway ME, Neckers LM, Loke SL, Al-Nasser AA, Redner RL, Shiramizu BT, Goldschmidts WL, Huber BE, Bhatia K, Magrath IT (1990) Tumor-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide. Lancet 335:808–811

    PubMed  Google Scholar 

  53. Meeker TC, Shiramizu B, Kaplan L, Headier B, Sanchez H, Grimaldi JC, Baumgartner J, Rachlin J, Feigal E, Rosenblum M, McGrath MS (1991) Evidence for molecular subtypes of HIV-associated lymphoma: division into peripheral monoclonal, polyclonal, and central nervous system lymphoma. AIDS 5:669–674

    PubMed  Google Scholar 

  54. National Cancer Institute (1982) National Cancer Institute-sponsored study of classification of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical use. Cancer 49:2112–2135

    Google Scholar 

  55. Neri A, Barriga F, Inghirami G, Knowles DM, Neequaye J, Magrath IT, Dalla-Favera R (1991) Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency associated-lymphoma. Blood 77:1092–1095

    PubMed  Google Scholar 

  56. Neri A, Barriga F, Knowles DM, Magrath IT, Dalla-Favera R (1988) Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct forms of Burkitt lymphoma. Proc Natl Acad Sci USA 85:2748–2752

    PubMed  Google Scholar 

  57. Ng VL, Hurt MH, Fein CL, Khayam-Bashi F, Marsh J, Nunes WM, McPhaul LW, Feigal E, Nelson P, Herndier BG, Shiramizu B, Reyes GR, Fry KE, McGrath MS (1994) IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig-binding specificity and VH-gene putative somatic mutation analysis. Blood 83:1067–1078

    PubMed  Google Scholar 

  58. Offit K, Jhanwar S, Ebrahim SAD, Filippa D, Clarkson BD, Chaganti RSK (1989) t(3;22)(q27;qll), a novel translocation associated with diffuse non-Hodgkin's lymphoma. Blood 74:1876–1879

    PubMed  Google Scholar 

  59. Offit K, Parsa NZ, Gaidano G, Filippa D, Louie D, Pan D, Jhanwar SC, Dalla-Favera R, Chaganti RSK (1993) 6q Deletions define distinct clinicopathologic subsets of non-Hodgkin's lymphoma. Blood 82:2157–2162

    PubMed  Google Scholar 

  60. Patton DF, Wilkowski CW, Hanson CA, Shapiro R, Gajl-Peczalska KJ, Filipovich AH, McKlain KL (1990) Epstein-Barr virus-determined clonality in posttransplant lympho-proliferative disease. Transplantation 49:1080–1084

    PubMed  Google Scholar 

  61. Pedersen C, Gerstroft J, Luundgren JD, Skinhøj P, Bøttzauw J, Geisler C, Hamilton-Dutoit SJ, Thorsen S, Lisse I, Ralf-kiaer E, Pallesen G (1991) HIV-associated lymphoma: histo-pathology and association with Epstein-Barr virus genome related to clinical, immunological and prognostic features. Eur J Cancer 27:1416–1423

    PubMed  Google Scholar 

  62. Pelicci P-G, Knowles DM, Arlin ZA, Wieczorek R, Luciw P, Dina D, Basilico C, Dalla-Favera R (1986) Multiple monoclonal B cell expansions and c-myc rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders: implications for lymphomagenesis. J Exp Med 164:2049–2076

    PubMed  Google Scholar 

  63. Pelicci PG, Knowles DM, Magrath IT, Dalla-Favera R (1986) Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci USA 83:2984–2988

    PubMed  Google Scholar 

  64. Penn I (1990) Cancers complicating organ transplantation. N Engl J Med 323:1767–1769

    PubMed  Google Scholar 

  65. Pluda JM, Yarchoan R, Jaffe ES, Feuerstein IM, Solomon D, Steinberg SM, Wyvill KM, Raubitschek A, Katz D, Broder S (1990) Development of non-Hodgkin's lymphoma in a cohort of patients with severe HIV infection on long-term anti-retroviral therapy. Ann Intern Med 113:276–282

    PubMed  Google Scholar 

  66. Ragni MV, Belle SH, Jaffe RA, Duerstein SL, Bass DC, McMillan CW, Lovrien EW, Aledort LM, Kisker CT, Stabler SP, Hoots WK, Hilgartner MW, Cox-Gill J, Buchanan GR, Sanders NL, Brettler DB, Barron LE, Goldsmith JC, Ewenstein B, Smith KJ, Green D, Addiego JE, Kingsley LA (1993) Acquired immunodeficiency syndrome-associated non-Hodgkin's lymphomas and other malignancies in patients with hemophilia. Blood 81:1889–1897

    PubMed  Google Scholar 

  67. Raphael BG, Knowles DM (1990) Acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma. Semin Oncol 3:361–366

    Google Scholar 

  68. Ree HJ, Strauchen JA, Khan AA, Gold JE, Crowley JP, Kahn H, Zalusky R (1991) Human immunodeficiency virus-associated Hodgkin's disease. Cancer 67:1614–1621

    PubMed  Google Scholar 

  69. Riboldi P, Gaidano G, Schettino EW, Steger TG, Knowles DM, Dalla-Favera R, Casali P (1994) Two AIDS-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins utilizing somatically mutated VH4-21 segments. Blood 83:2952–2961

    PubMed  Google Scholar 

  70. Saglio G, Borrello MG, Guerrasio A, Sozzi G, Serra A, Francia di Celle P, Foa R, Ferrarini M, Roncella S, Borgna Pignatti C, Marradi P, Izzo P, Soler J, Pierotti M (1993) Preferential clustering of chromosomal breakpoints in Burkitt's lymphomas and L3-type acute lymphoblastic leukemias with a t(8;14) translocation. Genes Chromosomes Cancer 8:1–7

    PubMed  Google Scholar 

  71. Schouten HC, Sanger WG, Weisenburger DD, Armitage JO (1990) Abnormalities involving chromosome 6 in newly diagnosed patients with non-Hodgkin's lymphoma. Cancer Genet Cytogenet 47:73–82

    PubMed  Google Scholar 

  72. Shibata M, Weiss LM, Nathwani BN, Brynes RK, Levine AM (1991) Epstein-Barr virus in benign lymph-node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma. Blood 77:1527–1533

    PubMed  Google Scholar 

  73. Shibata D, Weiss LM, Hernandez AM, Nathwani BN, Bernstein L, Levine AM (1993) Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus. Blood 81:2102–2109

    PubMed  Google Scholar 

  74. Subar M, Neri A, Inghirami G, Knowles DM, Dalla-Favera R (1988) Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDS-associated lymphoma. Blood 72:667–671

    PubMed  Google Scholar 

  75. Weiss LM, Mohaved LA (1989) In situ demonstration of Epstein-Barr viral genomes in viral-associated B-cell lympho-proliferations. Am J Pathol 134:651–656

    PubMed  Google Scholar 

  76. Yarchoan R, Venzon DJ, Pluda JM, Lietzau J, Wyvill KM, Tsiatis AA, Steinberg SM, Broder S (1991) CD4 count as a mortality indicator in human immunodeficiency virus (HIV)- infected patients receiving anti-retroviral therapy: experience in a research hospital. Ann Intern Med 115:184–189

    PubMed  Google Scholar 

  77. Ye BH, Rao PH, Chaganti RSK, Dalla-Favera R (1993) Cloning of BCL-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res 53:2732–2735

    PubMed  Google Scholar 

  78. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R (1993) Alterations of a novel zinc-finger encoding gene, BCL-6, in diffuse large cell lymphoma. Science 262:747–750

    PubMed  Google Scholar 

  79. Ziegler JL, Beckstaed JA, Volderbing PA, Abrams DI, Le-vine AM, Lukes RJ, Gill PS, Burkes RL, Meyer PR, Metroka CE, Mouradian J, Moore A, Riggs SA, Butler JJ, Cabanillas F, Hersh E, Newell GR, Laubenstein LJ, Knowles DM, Odajnyk C, Raphael B, Koziner B, Urmacher C, Clarkson BD (1982) Outbreak of Burkitt's-like lymphoma in homosexual men. Lancet 2:631–634

    PubMed  Google Scholar 

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  1. Department of Biomedical Sciences and Human Oncology, University of Turin, Medicina Interna-Sezione 5A, Ospedale San Luigi Gonzaga, Regione Gonzole 10, I-10043, Orbassano-Turin, Italy

    G. Gaidano & G. Saglio

  2. Laboratory of Medicine and Molecular Oncology, Clinical Section, Department of Biomedical Sciences and Human Oncology, University of Turin, Italy

    C. Pastore & C. Lanza

  3. Internal Medicine, Department of Clinical and Biomedical Sciences, University of Turin, Italy

    U. Mazza

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Gaidano, G., Pastore, C., Lanza, C. et al. Molecular pathology of AIDS-related lymphomas. Ann Hematol 69, 281–290 (1994). https://doi.org/10.1007/BF01696556

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