Abstract
Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients who showed hemolysis due to antiglobulin test-positive and test-negative AIHA, respectively. AIHA should be considered as one cause of anemia in de novo AML patients, and blood transfusions should be given carefully in such cases to avoid harmful hemolysis.
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References
Arbaje YM, Beltran G (1990) Chronic myelogenous leukemia complicated by autoimmune hemolytic anemia. Am J Med 88:197–199
Ben-Ishay D, Freund M, Groen JJ (1963) A case of autoimmune hemolytic anemia with circulating cold agglutinins presenting for many years as “hypersplenism” and terminating in leukemia. Blood 22:100–108
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1985) Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 103:626–629
Blackstock AM, Garson OM (1974) Direct evidence for involvement of erythroid cells in acute myeloblastic leukaemia. Lancet 2:1178–1179
Boccardi V, Papa G, Antonelli S, Girelli G, Liso V, Manoelli F (1977) Autoimmune hemolytic anemia followed by myelomonocytic leukemia. Haematologica (Pavia) 62:88–94
Dacie J (1992) Auto-immune haemolytic anaemia (AIHA): warm-antibody syndromes. VI. Coombs-negative (DAT-negative) haemolytic anaemia; positive direct antiglobulin tests in normal subjects and in hospital patients; polyagglutinability and haemolytic anaemia. In: Dacie J (ed) The haemolytic anaemias, 3rd edn. Churchill Livingstone, New York, pp 183–209
Foerster J (1993) Autoimmune hemolytic anemias. In: Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN (eds) Wintrobe's clinical hematology, 9th edn. Lea & Febiger, Philadelphia, pp 1170–1196
Frumin AM, Kohn A (1955) Autoimmune hemolytic disease in acute leukemia. Arch Intern Med 95:326–327
Hertenstein B, Kurrle E, Redenbacher M, Arnold R, Heimpel H (1993) Pseudoreticulocytosis in a patient with myelodysplasia. Ann Hematol 67:127–128
Mangal AK, Buskard NA (1984) Acute myeloblastic leukaemia and autoimmune haemolytic anaemia. Clin Lab Haematol 6:89–91
Omi T, Kajii E, Oyamada T, Kamesaki T, Ikemoto S (1992) Quantitation of red blood cell-associated IgG in autoimmune hemolytic anemia of warm type by an immunoradiometric assay. Jpn J Transfusion Med 38:601–606
Pirofsky B (1968) Autoimmune hemolytic anemia and neoplasia of the reticuloendothelium. Ann Intern Med 68:109–121
Pirofsky B (1969) Autoimmunization and the autoimmune hemolytic anemias. Williams & Wilkins, Baltimore, pp 108–117
Sokol RJ, Hewitt S, Booker DJ (1989) Erythrocyte autoantibodies, autoimmune haemolysis, and myelodysplastic syndromes. J Clin Pathol 42:1088–1091
Solal-Celigny P, Vazeux R, Vroclans M, Amar M, Herrera A (1984) Positive Coombs test in acute leukaemia. Br J Haematol 57:563–569
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Tamura, H., Ogata, K., Yokose, N. et al. Autoimmune hemolytic anemia in patients with de novo acute myelocytic leukemia. Ann Hematol 72, 45–47 (1996). https://doi.org/10.1007/BF00663016
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DOI: https://doi.org/10.1007/BF00663016