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Isolated meningeal chloroma (granulocytic sarcoma) – a case report and review of the literature

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Abstract

Isolated chloromas (granulocytic sarcomas) are rare tumors, most of them progressing to acute myeloblastic leukemia within months. There are still no conclusive treatment strategies for this entity; however, early antileukemic chemotherapy seems to lower the probability of developing systemic disease and prolong survival. We report on a patient with isolated meningeal chloroma, primarily misdiagnosed as a high-grade Non-Hodgkin's lymphoma. Two cycles of antileukemic induction chemotherapy were administered, followed by local irradiation and intensified consolidation therapy with autologous stem cell transplantation. After 20 months, he is still in complete remission.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Georg-August University, Robert-Koch-Str. 40, D-37075 Göttingen, Germany e-mail: cbinder@med.uni-goettingen.de Fax: +49-551-392914, , , , , , DE

    C. Binder & D. Haase

  2. Institute of Hematopathology, Christian-Albrecht-University, Kiel, Germany, , , , , , DE

    M. Tiemann

  3. 2nd Medical Clinic, Christian-Albrecht-University, Kiel, Germany, , , , , , DE

    A. Humpe & M. Kneba

Authors
  1. C. Binder
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  2. M. Tiemann
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  3. D. Haase
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  4. A. Humpe
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  5. M. Kneba
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Additional information

Received: 29 September 1999 / Accepted: 23 December 1999

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Binder, C., Tiemann, M., Haase, D. et al. Isolated meningeal chloroma (granulocytic sarcoma) – a case report and review of the literature. Ann Hematol 79, 459–462 (2000). https://doi.org/10.1007/s002770000165

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  • DOI: https://doi.org/10.1007/s002770000165

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