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Serum SH reactivity: A simple assessment of D-penicillamine absorption?

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Summary

A simple biochemical technique is described, which reflects the levels of D-penicillamine in the serum of patients with rheumatoid arthritis treated with this drug. The assay is based on the ability of D-penicillamine to stimulate the rate of reaction between serum sulphydryl groups and Ellman's reagent (DTNB). Using this technique, co-administration of oral ferrous sulphate has been shown to block D-penicillamine absorption. The assay provides useful information for the evaluation of a patient's clinical response to D-penicillamine treatment.

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Authors and Affiliations

  1. ARC Research Group, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, BA1 1RL, Bath, UK

    N. D. Hall, D. R. Blake, G. J. M. Alexander, C. Vaisey & P. A. Bacon

  2. Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, BA2 7AY, Bath, UK

    N. D. Hall, D. R. Blake, G. J. M. Alexander, C. Vaisey & P. A. Bacon

Authors
  1. N. D. Hall
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  2. D. R. Blake
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  3. G. J. M. Alexander
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  4. C. Vaisey
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  5. P. A. Bacon
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Hall, N.D., Blake, D.R., Alexander, G.J.M. et al. Serum SH reactivity: A simple assessment of D-penicillamine absorption?. Rheumatol Int 1, 39–41 (1981). https://doi.org/10.1007/BF00541222

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  • DOI: https://doi.org/10.1007/BF00541222

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