Summary
C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum albumin (BSA) ICs, or with the prevention of immune precipitation of BSA or alkaline phosphatase ICs, nor with immune adherence assayed using thyroglobulin and BSA ICs.
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Holme, E.R., Veitch, J., Johnston, A. et al. The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence. Rheumatol Int 12, 187–190 (1992). https://doi.org/10.1007/BF00302150
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DOI: https://doi.org/10.1007/BF00302150