Summary
A statistically significant association of clinical rheumatoid vasculitis (excluding nodules or nail-fold infarcts only) with the HLA B8 DR3 phenotype was found when comparing 30 patients with vasculitis with 84 classic or definite rheumatoid patients without clinical vasculitis. The previously reported association on HLA DR4 with rheumatoid disease was also confirmed.
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References
Weisman MH, Zvaifler NJ (1980) Vasculitis in connective tissue diseases. Clin Rheum Dis 6:351–371
Kulka JP (1959) The vascular lesion associated with rheumatoid arthritis. Bull Rheum Dis 10:201–204
Bywaters EGL, Scott JT (1963) The natural history of vascular lesions in rheumatoid arthritis. J Chronic Dis 16: 905–914
Gordon DA, Stein JL, Broder I (1973) The extra-articular features of rheumatoid arthritis. Am J Med 54:445–542
Scott DGI, Bacon PA, Allen C, Elson CJ, Wallington T (1981) IgG rheumatoid factor, complement and immune complexes in rheumatoid synovitis and vasculitis; Comparative and serial studies during cytotoxic therapy. Clin Exp Immunol 43:54–63
Panayi GS, Wooley P, Batchelor JR (1978) Genetic basis of rheumatoid disease: HLA antigens, disease manifestations and toxic reactions of drugs. Br Med J 2:1326–1328
Batchelor JR, Morris PJ (1978) In: Bodmer WF, Budmu JG, Batchelor JR, Festenstein H, Morris PJ (eds) Histocompatibility testing 1977. Munksgaard, Copenhagen, pp 205–258
Goldberg MA, Arnett FC, Bias WB, Shulman LE (1976) Histocompatibility antigens in systemic lupus erythematosus. Arthritis Rheum 19:129–132
Reinertsen JL, Klippel JH, Johnson AH, Steinberg AD, Decker JL, Mann DL (1978) B-lymphocyte alloantigens associated with systemic lupus erythematosus. N Engl J Med 299:515–518
Whittingham S, Mathews JD, Schanfield MS, Tait BD, MacKay IR (1981) Interaction of HLA, Gm in autoimmune chronic active hepatitis. Clin Exp Immunol 43:80–86
Glass D, Soter NA, Gibson D, Carpenter LB, Schur PH (1978) Association between HLA and cutaneous necrotizing venulitis. Arthritis Rheum 19:945–949
Scott DGI, Bacon PA, Tribe CR (1981) Systemic rheumatoid vasculitis. A clinical and laboratory study of 50 cases. Medicine 60:288–297
Dausset J, Contu L (1980) The MHC and immune response in man, vol 80, Immunology. Academic Press, London
Lawley TJ, Hall RP, Fauci AS, Katz SI, Hamburger MI, Frank MM (1981) Defective Fc receptor functions associated with the HLA B8 DR3 haplotypes. N Engl J Med 304:185–191
Legrand L, Hors J, Dausset J (1980) IVth Int Congr Immunol, Paris (Abstr)
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Cunningham, T.J., Tait, B.D., Mathews, J.D. et al. Clinical rheumatoid vasculitis associated with the B8 DR3 phenotype. Rheumatol Int 2, 137–139 (1982). https://doi.org/10.1007/BF00541167
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DOI: https://doi.org/10.1007/BF00541167