Skip to main content
SpringerLink
Log in

IGM-containing immune complexes and antiphospholipid antibodies in patients with Sneddon's syndrome

  • Case Reports
  • Published:
Rheumatology International Aims and scope Submit manuscript

Summary

We report three patients with a Sneddon syndrome in whom predominantly small (500–900 kD) IgM-containing serum immune complexes were detectable. Furthermore, antiphospholipid antibodies and increased von Willebrand factor antigen were found in the sera of two cases. Especially the data demonstrating small circulating immune complex as suggest that Sneddon's syndrome, a rare vasculitis disorder, might immunologically be characterized by circulating IgM-containing immune complexes which, in addition, could play a role in the pathogenesis of this disease entity. The elevated antiphospholipid antibodies as well as the increased von Willebrand factor antigen in the sera of the investigated patients have to be considered as nonspecific vasculitis-associated phenomena.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ehrmann S (1912) Weitere Mitteilungen über syphilitische Veränderungen der Hautgefäße und die damit zusammenhängenden Phänomene. Arch Derm Syph 113:261

    Google Scholar 

  2. Adamson HG (1912) Modern viewes upon the significance of skin eruptions. Lancet I:1041–1048

    Google Scholar 

  3. Church RE (1962) Reticular livedo with cerebro-vascular lesions. Br J Dermatol 74:156–157

    Google Scholar 

  4. Champion RH (1965) Livedo reticularis: A review. Br J Dermatol 77:167–179

    Google Scholar 

  5. Sneddon IB (1965) Cerebrovascular lesions and livedo reticularis. Br J Dermatol 77:180–185

    Google Scholar 

  6. Thomas DJ, Kirby JDT, Britten KE, Galton DJ (1982) Livedo reticularis and neurological lesions. Br J Dermatol 106:711–712

    Google Scholar 

  7. Lubach D, Stamm T (1981) Neurologische Veränderungen bei Livedo racemosa generalisata (Ehrmann). Hautarzt 32:245–248

    Google Scholar 

  8. Rumpl E, Rumpl H (1979) Recurrent transient global amnesia in a case with cerebrovascular lesion and livedo reticularis (Sneddon's syndrome). J Neurol 221:127

    Google Scholar 

  9. Rebello M, Val JF, Garijo F, Quintana F, Berciano J, Livedo syndrome. Brain 106:965–979

  10. Rumpl E, Neuhofer J, Pallua A, Willeit J, Vogl G, Stampfel G, Platz T (1985) Cerebrovascular lesions and livedo reticularis (Sneddon's syndrome) — a progressive cerebrovascular disorder? J Neurol 231:324–330

    Google Scholar 

  11. Zubler RH, Lange G, Lambert PH, Miescher PA (1976) Detection of immune complexes in unheated sera by a modified 125J-C1q-binding test. J Immunol 116:232

    Google Scholar 

  12. Krapf FE, Rengert D, Schedel I, Leiendecker K, Leyssens H, Deicher H (1982) A PEG-precipitation laser nephelometer technique for detection and characterisation of circulating immune complexes in human sera. J Immunol Methods 54:107

    Google Scholar 

  13. Gharavi AE, Harris EN, Asherson RA, Hughes GRV (1987) Anticardiolipin antibodies: Isotype distribution and phospholipid specificity. Ann Rheum Dis 46:1–6

    Google Scholar 

  14. Cejka J (1982) Enzyme immunoassay for factor VIII-related antigen. Clin Chem 28:1356–1358

    Google Scholar 

  15. Jonas J, Kölble K, Völcker HE, Kalden JR (1986) Central retinal artery occlusion in Sneddon's disease associated with antiphospholipid antibodies. Am J Ophthalmol 102:37–40

    Google Scholar 

  16. Stephens WP, Ferguson JT (1982) Livedo reticularis and cerebrovascular disease. Postgrad Med J 58:70–73

    Google Scholar 

  17. Drake ME (1982) Winiwarter-Buerger disease (thrombangitis obliterans) with cerebral involvement. JAMA 248:1870–1872

    Google Scholar 

  18. Biller J, Asconape J, Challa VR, Toole JF, McLean WT (1981) A case for cerebral thrombangitis obliterans. Stroke 12:686–689

    Google Scholar 

  19. Pinol Aguade J, Ferrandiz C, Ferrer Roca O, Ingelmo M (1975) Livedo reticularis y accidentes cerebro-vasculares. Med Cutan Ibero Lat Am 3:257–265

    Google Scholar 

  20. Conley CL, Hartmann RC (1952) A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest 31:621–622

    Google Scholar 

  21. Mueh JR, Herbst KD, Rapaport SI (1980) Thrombosis in patients with the lupus anticoagulant. Ann Intern Med 92:156

    Google Scholar 

  22. Harris EN, Loizou S, Englert H, Derue G, Chan JK, Gharavi AE, Hughes GRV (1984) Anticardiolipin antibodies and lupus anticoagulant. Lancet 1099

  23. Lubbe WF, Butler WS, Palmer SJ, Liggins GC (1984) Lupus anticoagulant in pregnancy. Br J Obstet Gynaecol 91:357

    Google Scholar 

  24. Harris EN, Gharavi AE, Hughes GRV (1985) Antiphospholipid antibodies. Clin Rheum Dis 11:591–609

    Google Scholar 

  25. Asherson RA, Mercey D, Phillips G, Sheehan N, Gharavi AE, Harris EN, Hughes GRV (1987) Recurrent stroke and multiinfarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis 46:605–611

    Google Scholar 

  26. McHugh NJ, Maymo J, Skinner RP, James I, Maddison PJ (1988) Anticardiolipin antibodies, livedo reticularis, and major cerebrovascular and renal disease in systemic lupus erythematosus. Ann Rheum Dis 47:110–115

    Google Scholar 

  27. Anderson NE, Ali MR (1984) The lupus anticoagulant, pulmonary thrombembolism and fatal pulmonary hypertension. Ann Rheum Dis 43:760

    Google Scholar 

  28. Krapf FE (1984) Immunkomplexe: Entstehung, Eigenschaften, Bedeutung und Nachweis (Teil I und II). Lab Med 8:298–302, 341–345

    Google Scholar 

  29. Manger BJ, Krapf FE, Gramatzki M, Nüsslein HG, Burmester GR, Krauledat PB, Kalden JR (1985) IGE-containing circulating immune complexes in Churg-Strauß vasculitis. Scand J Immunol 21:369–373

    Google Scholar 

  30. Williams RC (1981) Immune complexes: a clinical perspective. Am J Med 71:743–746

    Google Scholar 

  31. WHO (1978) A WHO collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum. J Clin Lab Immunol 1:1–3

    Google Scholar 

  32. Brinkhous KM, Sultzer DL, Reddick RL, Griggs TR (1980) Elevated plasma von Willebrand factor levels as an index of acute endothelial injury: use of a hypotonic injury model in rats. Fed Proc 39:630 (abstr)

    Google Scholar 

  33. Woolfe AD, Wakerley G, Wallington TB, Scott DGI, Dieppe PA (1987) Factor III related antigen in the assessment of vasculitis. Ann Rheum Dis 46:411–447

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department for Clinical Immunology and Rheumatology, University of Erlangen-Nürnberg, Krankenhausstrasse 12, D-8520, Erlangen, Federal Republic of Germany

    E. Schulze-Lohoff, F. Krapf, L. Bleil, G. R. Burmester, K. Kölble, H. G. Nüßlein & J. R. Kalden

  2. X-Ray Department, Department for Internal Medicine, University of Erlangen-Nürnberg, Krankenhausstrasse 12, D-8520, Erlangen, Federal Republic of Germany

    W. Rödl

Authors
  1. E. Schulze-Lohoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Krapf
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Bleil
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. R. Burmester
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Kölble
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. G. Nüßlein
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. Rödl
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. R. Kalden
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schulze-Lohoff, E., Krapf, F., Bleil, L. et al. IGM-containing immune complexes and antiphospholipid antibodies in patients with Sneddon's syndrome. Rheumatol Int 9, 43–48 (1989). https://doi.org/10.1007/BF00270289

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00270289

Key words

Search

Navigation