Abstract
The authors report a rate case of carcinoid syndrome (CS) in a 12-year-old child that was caused by a carcinoid tumor located in the ileum that had metastasized mainly to the liver. After resection of the primary tumor, treatment with octreotide and polychemotherapy (five monthly cycles of 5-flourouracil, epidoxorubicin, and deticene) was ineffective for both reducing the metastatic liver disease and controlling the clinical symptoms. The patient's poor prognosis led the authors to perform a liver transplantation. The results of liver transplantation in patients with metastatic liver disease are generally not good. However, neuroendocrine tumors seem to be an exception due to their slow growth. At present, the child is in complete clinical and laboratory remission 4 months after transplantation. To the best of our knowledge, only 5 cases of CS have been reported to date in children.
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Alsina AE, Bartus S, Hull D (1990) Liver transplant for metastatic neuroendocrine tumor. J Clin Gastroenterol 12: 533–537
Barber DH, Michener WM (1965) Malignant argentaffinoma — report of a case of an 11 year old boy. Cleve Clin Q 32: 143–147
Biorck G, Axen D, Thomson A (1952) Unusual cyanosis in a boy with congenital pulmonary stenosis and tricuspid insufficiency: fatal outcome after angiocardiography. Am Heart J 44: 143–148
Chow CW, Sane S, Campbell PE, et al (1982) Malignant carcinoid tumors in children. Cancer 49: 802–811
Field JL, Adamson LF, Stoeckle HE (1962) Review of carcinoids in children. Functioning carcinoid in a 15 year old male. Pediatrics 29: 953–960
Grahame-Smith DG (1977) The carcinoid syndrome. In: Truelove SC, Lee E (eds) Topics in gastroenterology. Blackwell, Oxford, pp 285–312
King MD, Young DG, Hann IM (1985) Carcinoid syndrome: an unusual cause of diarrhoea. Arch Dis Child 60: 269–271
Kvols LK, Moertel CG, O'Connel MJ (1986) Treatment of the malignant carcinoid syndrome. N Engl J Med 315: 663–666
Jonsson T, Johannsson J, Hallgrimsson J (1989) Carcinoid of the appendix in children younger than 16 years. Acta Chir Scand 155: 113–116
Moertel CG (1983) Treatment of the carcinoid tumor and malignant carcinoid syndrome. J Clin Ocol 1: 727–740
Parkers SE, Muir KR, Al Sheyyab M, et al (1993) Carcinoid tumors of thel appendix in children. Br J Surg 80: 502–504
Wu L, Steven D (1993) Curcinoid tumors. In: Niederhuber J (ed) Current therapy in oncology. Mosby, St. Louis, pp 258–263
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Granata, C., Haupt, R., Mazzaferro, V. et al. Carcinoid syndrome. Pediatr Surg Int 11, 398–399 (1996). https://doi.org/10.1007/BF00497825
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DOI: https://doi.org/10.1007/BF00497825