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Hirschsprung's disease as a neurochristopathy

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Abstract

Recent molecular-genetic and histochemical studies of intestinal aganglionosis have confirmed the initial classification established by Bolande, who considered Hirschsprung's disease (HD) a neurocristopathy.

This paper is a critical review of the results of molecular-genetic studies carried out from 1992 to date. In particular, the author focuses on the possible clinical impact of the identification ofRET as a causative gene for HD.

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  1. Department of Pediatric Surgery, Istituto Giannina Gaslini, Largo Gaslini 5, I-16147, Genova, Italy

    G. Martucciello

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Martucciello, G. Hirschsprung's disease as a neurochristopathy. Pediatr Surg Int 12, 2–10 (1997). https://doi.org/10.1007/BF01194793

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