Summary
In five cases of dystrophia myotonica electron microscope preparations of muscle taken at biopsy showed both centrally placed and subsarcolemmal nuclei containing complex vacuolar areas enclosing myofibrillar material. It is suggested that this appearence, which has not been seen in any other condition, may be due to the forcing of myofibrillar material into the nucleus during its migration to the centre of the fibre invaginating but not breaching its membrane.
Zusammenfassung
In fünf Fällen von Dystrophia myotonica zeigte die elektronenoptische Untersuchung von bioptisch entnommenem Material zentrale und subsarkolemmale Kerne, die komplexe vacuoläre Areale um myofibrilläres Material enthalten. Diese bisher nicht beobachtete Veränderung könnte durch Verlagerung von myofibrillärem Material in den Kern während seiner Wanderung in das Faserzentrum durch Invagination, aber nicht Durchbrechung der Kernmembran bedingt sein.
References
Aleu, P., andK. Afifi: Ultrastructure of muscle in myotonic dystrophy. Amer. J. Path.45, 221–231 (1964).
Klinkerfuss, George H.: An electron microscopic study of myotonic dystrophy. Arch. Neurol. (Chic.)16, 181–193 (1967).
Milhaud, M., M. Fardeau etJ. Lapresle: Contribution à l'étude des lésions élémentaires du muscle squelettique. Ultrastructure des fibres annulaires (observées dans la dystrophie myotonique). C. R. Soc. Biol. (Paris)158, 2274–2275 (1967).
Wechsler, W., u.H. Hager: Electronenmikroscopische Untersuchungen bei myotonischer Muskeldystrophie. Arch. Psychiat. Nervenkr.201, 668–690 (1960/1961).
Woolf, A. L.: Muscle biopsy in “Modern trends in neurology”, p. 18. Ed.D. Williams. London: Butterworth 1962.
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In receipt of grants from the National Fund for Research into Poliomyelitis and other Crippling Diseases and from the Medical Research Council.
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Johnson, A.G., Woolf, A.L. Abnormal sarcolemmal nuclei encountered in several cases of dystrophia myotonica. Acta Neuropathol 12, 183–188 (1969). https://doi.org/10.1007/BF00692505
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DOI: https://doi.org/10.1007/BF00692505