Skip to main content
SpringerLink
Log in

Structural changes of the central nervous system in swayback (enzootic Ataxia) of lambs

V. Electron microscopic observations of the corpus callosum

  • Original Investigations
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

An electron microscopic study of the corpus callosum of normal and swayback lambs has revealed morphological evidence of normal myelinogenesis in both groups of animals. Axons wrapped by two cell processes were frequently encountered. Reactive changes were found in axons in the swayback lambs. The significance of these findings is discussed.

Zusammenfassung

Elektronenmikroskopische Untersuchung des Corpus callosum normaler Lämmer und von solchen mit „Swayback” (enzootische Ataxia) ergab den morphologischen Nachweis normaler Myelinentwicklung in beiden Tiergruppen. Von zwei Zellfortsätzen umgebene Axone wurden häufig beobachtet. Reaktive Veränderungen wurden in Axonen der „Swayback”-Lämmer gefunden. Die Bedeutung dieser Befunde wird besprochen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bunge, M. B., R. P. Bunge, andH. Ris: Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord. J. biophys. biochem. Cytol.10, 67–94 (1961).

    Google Scholar 

  • Cancilla, P. A., andR. M. Barlow: Structural changes of the central nervous system in swayback (Enzootic Ataxia) of lambs. II. Electron microscopy of the lower motor neuron. Acta neuropath. (Berl.)6, 251–259 (1966a).

    Google Scholar 

  • ——: Structural changes of the central nervous system in swayback (Enzootic Ataxia) of lambs. III. Electron microscopy of the cerebral lesions. Acta neuropath. (Berl.)6, 260–265 (1966b).

    Google Scholar 

  • ——: Structural changes of the central nervous system in swayback (Enzootic Ataxia) of lambs. IV. Electron microscopy of the white matter of the spinal cord. Acta neuropath. (Berl.)11, 294–300 (1968).

    Google Scholar 

  • Hirano, A., andH. M. Dembitzer: A structural analysis of the myelin sheath in the central nervous system. J. Cell Biol.34, 555–567 (1967).

    Google Scholar 

  • Holtzman, E., andA. B. Novikoff: Lysosomes in the rat sciatic nerve following crush. J. Cell Biol.27, 651–669 (1965).

    Google Scholar 

  • Innes, J. R. M., andL. Z. Saunders: In: Comparative Neuropathology. New York-London: Academic Press 1962.

    Google Scholar 

  • —, andG. D. Shearer: Swayback, a demyelinating disease of lambs with affinities to Schilder's disease. J. comp. Path.53, 1–41 (1940).

    Google Scholar 

  • Lampert, P. W.: Demyelination and remyelination in experimental allergic encephalomyelitis. Further electron microscopic observations. J. Neuropath. exp. Neurol.24, 371–385 (1965).

    Google Scholar 

  • —: A comparative electron microscopic study of reactive, degenerating, regenerating and dystrophic axons. J. Neuropath. exp. Neurol.26, 345–368 (1967).

    Google Scholar 

  • —, andS. Carpenter: Electron microscopic studies on the vascular permeability and the mechanism of demyelination in experimental allergic encephalomyelitis. J. Neuropath. exp. Neurol.24, 11–24 (1965).

    Google Scholar 

  • Maturana, H. R.: The fine anatomy of the optic nerve of Anurans. An electron microscopic study. J. biophys. biochem. Cytol.7, 107–120 (1960).

    Google Scholar 

  • Peters, A.: Observations on the connections between myelin sheaths and glial cells in the optic nerves of young rats. J. Anat. (Lond.)98, 125–134 (1964).

    Google Scholar 

  • Romanes, G. J.: The prenatal medullation of the sheep's nervous system. J. Anat. (Lond.)81, 64–81 (1947).

    Google Scholar 

  • Ross, L. L., M. B. Bornstein, andG. M. Lehrer: Electron microscopic observations of rat and mouse cerebellum in tissue culture. J. Cell Biol.14, 19–30 (1962).

    Google Scholar 

  • Schultz, R. L., E. A. Maynard, andD. C. Pease: Electron microscopy of neurons and neuroglia of cerebral cortex and corpus callosum. Amer. J. Anat.100, 369–407 (1957).

    Google Scholar 

  • Webster, H. de F.: Transient focal accumulation of axonal mitochondria during the early stages of Wallerian degeneration. J. Cell Biol.12, 361–383 (1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Departments of Pathology and Neurology, University of Utah College of Medicine, 50 North Medical Drive, 84112, Salt Lake City, USA

    P. A. Cancilla

  2. The Moredun Research Institute, Edinburgh, Scotland

    R. M. Barlow

Authors
  1. P. A. Cancilla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Barlow
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This investigation was supported by Grant No. 460 from the National Multiple Sclerosis Society and the United States Public Health Research Grants HE-05609 and CA-05321 and in part by contributions from the Eleanor Roosevelt Cancer Research Foundation

The authors would like to thankD. Every, J. Kolb andC. Cochran for fine technical assistance

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cancilla, P.A., Barlow, R.M. Structural changes of the central nervous system in swayback (enzootic Ataxia) of lambs. Acta Neuropathol 12, 307–313 (1969). https://doi.org/10.1007/BF00809127

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00809127

Key-Words

Search

Navigation