Summary
The incorporationin vivo of14C-glycine into proteins has been studied during the period before and after the onset of neurotoxicity caused by an organic mercury compound and byp-bromophenylacetylurea in rats. The observations of Yoshinoet al. (1966) on the former intoxication have been confirmed in that an impairment of glycine incorporation into proteins was present in spinal ganglion cells, and may also be taking place in other tissues, before nerve fibre degeneration takes place.
A similar reduction in amino acid incorporation into proteins during the period before the onset of paralysis due top-bromophenylacetylurea is found in spinal ganglia; this finding is confirmed by anin vitro method using14C-leucine as protein precursor.
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Cavanagh, J.B., Chen, F.C.K. Amino acid incorporation in protein during the “silent phase” before organo-mercury andp-bromophenylacetylurea neuropathy in the rat. Acta Neuropathol 19, 216–224 (1971). https://doi.org/10.1007/BF00684598
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DOI: https://doi.org/10.1007/BF00684598